Synthesis of Difluoromethylthioesters from Aldehydes
Synthesis of Difluoromethylthioesters from Aldehydes
复制标题
由醛合成二氟甲基硫酯
DOI：
10.1002/anie.201710731
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发表时间：
2018-02-05
影响因子：
16.6
通讯作者：
Wang, Yong-Qiang
中科院分区：
文献类型：
--
作者：
Guo, Shi-Huan;Zhang, Xing-Long;Wang, Yong-Qiang
二氟甲基硫酯化合物是另一类重要的有机氟化合物，本文首次报道。它们可以由各种醛有效地合成。该合成方法具有反应条件温和、对官能团耐受性好、底物范围广、重要的是反应中不涉及金属等特点。该方法有可能成为高级合成中间体后期功能化的重要工具，并应在药物化学中有许多应用。
Difluoromethylthioester compounds are yet another important kind of organofluorine compound and are reported here for the first time. They can be efficiently synthesized from various aldehydes. The synthetic method features mild reaction conditions, good tolerance of functional groups, broad substrate scope, and importantly, no metal is involved in the reaction. The approach has the potential to become an important tool for the late-stage functionalization of advanced synthetic intermediates, and should have many applications in medicinal chemistry.