Optimization of real-time acoustical and mechanical monitoring of high intensity focused ultrasound (HIFU) treatment using harmonic motion imaging for high focused ultrasound (HMIFU).
Optimization of real-time acoustical and mechanical monitoring of high intensity focused ultrasound (HIFU) treatment using harmonic motion imaging for high focused ultrasound (HMIFU).
复制标题
使用高聚焦超声 (HMIFU) 谐波运动成像优化高强度聚焦超声 (HIFU) 治疗的实时声学和机械监测。
DOI：
10.1109/embc.2013.6610989
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Konofagou,ElisaE
中科院分区：
文献类型：
--
作者：
Hou,GaryY;Marquet,Fabrice;Wang,Shutao;Konofagou,ElisaE
聚焦超声谐波运动成像（HMI）技术是近年来发展起来的一种高强度聚焦超声（HIFU）治疗监测方法，在体外和体内实验中均取得了良好的效果。其原理是基于利用治疗换能器发射调幅治疗超声波束以诱导振荡辐射力，同时使用共焦对准诊断换能器在HIFU治疗期间跟踪焦点组织机械响应。为了转化为临床实施的高强度聚焦超声，需要一个完整的评估研究，以调查最佳的辐射力阈值，可靠地监测局部组织的机械性能变化，即，在聚焦介质（即，沸腾、空化和非线性）。在这项研究中，高强度聚焦超声（HIFU）技术应用于HIFU治疗监测新鲜离体犬肝脏标本。为了进行多特征评估，诊断传感器作为脉冲回波成像仪或无源空化探测器（PCD）进行操作，以评估声学和机械响应，同时使用裸线热电偶监测焦点温度变化。当HIFU治疗的声功率范围为2.3至11.4 W时，在整个范围内观察到稳健的HMI位移。此外，发现高质量位移监测的优化范围在3.6至5.2W之间，其中位移显示出增加，然后显著减少，表明由于热损伤形成而导致的病灶介质硬化，而相关系数保持在0.95以上。
Harmonic Motion Imaging (HMI) for Focused Ultrasound (HMIFU) is a recently developed high-intensity focused ultrasound (HIFU) treatment monitoring method with feasibilities demonstrated in silica, in vitro and in vivo. Its principle is based on emission of an Amplitude-modulated therapeutic ultrasound beam utilizing a therapeutic transducer to induce an oscillatory radiation force while tracking the focal tissue mechanical response during the HIFU treatment using a confocally-aligned diagnostic transducer. In order to translate towards the clinical implementation of HMIFU, a complete assessment study is required in order to investigate the optimal radiation force threshold for reliable monitoring the local tissue mechanical property changes, i.e., the estimation HMIFU displacement under thermal, acoustical, and mechanical effects within focal medium (i.e., boiling, cavitation, and nonlinearity) using biological specimen. In this study, HMIFU technique is applied on HIFU treatment monitoring on freshly excised ex vivo canine liver specimens. In order to perform the multi-characteristic assessment, the diagnostic transducer was operated as either a pulse-echo imager or Passive Cavitation Detector (PCD) to assess the acoustic and mechanical response, while a bare-wire thermocouple was used to monitor the focal temperature change. As the acoustic power of HIFU treatment was ranged from 2.3 to 11.4 W, robust HMI displacement was observed across the entire range. Moreover, an optimized range for high quality displacement monitoring was found to be between 3.6 to 5.2W, where displacement showed an increase followed by significant decrease, indicating a stiffening of focal medium due to thermal lesion formation, while the correlation coefficient was maintained above 0.95.