Different Pedunculopontine Tegmental Neurons Signal Predicted and Actual Task Rewards
Different Pedunculopontine Tegmental Neurons Signal Predicted and Actual Task Rewards
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DOI：
10.1523/jneurosci.4415-08.2009
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发表时间：
2009-04-15
影响因子：
5.3
通讯作者：
Kobayashi, Yasushi
中科院分区：
文献类型：
--
作者：
Okada, Ken-ichi;Toyama, Keisuke;Kobayashi, Yasushi
多巴胺系统与基于奖励的指导行为有关。脑干的脚桥被盖核（PPTN）接收来自奖励相关结构（包括大脑皮质和基底节）的传入输入，并反过来向多巴胺神经元提供强兴奋性投射。这一解剖学证据预测，PPTN神经元可能携带奖励信息。为了阐明PPTN在奖励寻求行为中的功能作用，我们记录了单个PPTN神经元，而猴子执行视觉引导的扫视任务，其中预测的奖励值由固定目标的形状告知。两组不同的神经元，固定目标（FT）和奖励传递（RD）神经元，携带奖励信息。FT神经元的活动持续FT发作和奖励交付之间，与预期奖励的大小相关的活动水平。RD神经元在奖励传递后阶段性放电，其活动水平与实际奖励相关。这些结果表明，PPTN神经元信号的预测和实际奖励值，这两者都是必要的奖励预测误差的计算所代表的多巴胺神经元的单独的人口。
The dopamine system has been implicated in guiding behavior based on rewards. The pedunculopontine tegmental nucleus (PPTN) of the brainstem receives afferent inputs from reward-related structures, including the cerebral cortices and the basal ganglia, and in turn provides strong excitatory projections to dopamine neurons. This anatomical evidence predicts that PPTN neurons may carry reward information. To elucidate the functional role of the PPTN in reward-seeking behavior, we recorded single PPTN neurons while monkeys performed a visually guided saccade task in which the predicted reward value was informed by the shape of the fixation target. Two distinct groups of neurons, fixation target (FT) and reward delivery (RD) neurons, carried reward information. The activity of FT neurons persisted between FT onset and reward delivery, with the level of activity associated with the magnitude of the expected reward. RD neurons discharged phasically after reward delivery, with the levels of activity associated with the actual reward. These results suggest that separate populations of PPTN neurons signal predicted and actual reward values, both of which are necessary for the computation of reward prediction error as represented by dopamine neurons.