Proteinases as drug targets
Proteinases as drug targets
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蛋白酶作为药物靶点
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发表时间：
2012
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影响因子：
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通讯作者：
B. Dunn
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文献类型：
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作者：
B. Dunn
二肽基肽酶：人类健康和疾病的底物和治疗靶点然后呢?在炎症、心血管疾病、癌症和纤维化中的病理生理作用谷氨酸羧基肽酶II作为治疗靶点在补体逃避中针对二肽基肽酶-4 （DPP-4）和成纤维细胞激活蛋白（FAP）在糖尿病和癌症治疗中的作用半胱氨酸蛋白酶组织蛋白酶B作为阿尔茨海默病药物靶点的发现恶性疟原虫中性氨基肽酶从酶结构研究开发新型抗疟疾药物血食性人钩虫蛋白酶血食性人钩虫蛋白酶血水解失活丝氨酸蛋白酶的结构失活机制
Dipeptidyl peptidases: Substrates and therapeutic targeting in human health and disease The Metalloproteases Meprin ? and ?: Pathophysiological roles in Inflammation, Cardiovascular Disease, Cancer, and Fibrosis Glutamate Carboxypeptidase II as a Therapeutic Target The Role of Proteolytically Inactive Serine Proteases from Sarcoptes scabiei in Complement Evasion Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy Discovery of the Cysteine Protease Cathepsin B as a Drug Target for Alzheimer's Disease Plasmodium falciparum Neutral Aminopeptidases: Development of novel anti-malarials by understanding enzyme structure Blood-feeding human hookworm proteases Structural Mechanisms of Inactivation in Proteolytically Inactive Serine Proteases from Sarcoptes scabiei The Aspartic Proteinases from the Malaria Parasite: Structure and Function of the Plasmepsins