Becoming multicellular by aggregation;: The morphogenesis of the social amoebae Dicyostelium discoideum
Becoming multicellular by aggregation;: The morphogenesis of the social amoebae Dicyostelium discoideum
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DOI：
10.1023/a:1021259326918
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发表时间：
2002-01-01
影响因子：
1.8
通讯作者：
Weijer, CJ
中科院分区：
文献类型：
--
作者：
Dormann, D;Vasiev, B;Weijer, CJ
大多数生物体的组织和形式是在胚胎发育过程中产生的，涉及细胞分裂、细胞死亡、细胞分化和细胞运动的精确空间和时间控制。细胞运动的差异是形态生成中特别重要的机制。可以说，最容易理解的定向运动机制是趋化性。趋化性在社会性变形虫盘基网柄菌的饥饿诱导的多细胞发育中发挥着重要作用。饥饿时，多达 10(5) 个变形虫会聚集形成子实体。在本文中，我们回顾了以下证据：盘基网柄菌发育的所有阶段中细胞的运动是由 cAMP 的传播波控制的，cAMP 控制细胞的趋化运动。我们分析了细胞间信号传导之间复杂的相互作用，导致各种几何形状的 cAMP 波和细胞运动，从而导致信号源重新分布，从而改变波的几何形状。我们继续展示如何在细胞行为规则的层面上开始理解这种相对简单的生物体的形态发生，包括聚集流和土堆的形成、弹头的形成和迁移，这些规则可以通过模型计算进行实验和理论上的测试。
The organisation and form of most organisms is generated during their embryonic development and involves precise spatial and temporal control of cell division, cell death, cell differentiation and cell movement. Differential cell movement is a particularly important mechanism in the generation of form. Arguably the best understood mechanism of directed movement is chemotaxis. Chemotaxis plays a major role in the starvation induced multicellular development of the social amoebae Dictyostelium. Upon starvation up to 10(5) individual amoebae aggregate to form a fruiting body. In this paper we review the evidence that the movement of the cells during all stages of Dictyostelium development is controlled by propagating waves of cAMP which control the chemotactic movement of the cells. We analyse the complex interactions between cell-cell signalling resulting in cAMP waves of various geometries and cell movement which results in a redistribution of the signalling sources and therefore changes the geometry of the waves. We proceed to show how the morphogenesis, including aggregation stream and mound formation, slug formation and migration, of this relatively simple organism is beginning to be understood at the level of rules for cell behaviour, which can be tested experimentally and theoretically by model calculations.