Trends in Sigma-1 Receptor Research: A 25-Year Bibliometric Analysis
Trends in Sigma-1 Receptor Research: A 25-Year Bibliometric Analysis
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DOI：
10.3389/fphar.2019.00564
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发表时间：
2019-05-24
影响因子：
5.6
通讯作者：
Portillo-Salido, Enrique
中科院分区：
文献类型：
--
作者：
Romero, Luz;Portillo-Salido, Enrique
目的：以前的综述主要集中在Sigma-1受体，但没有文献计量学研究将该领域作为一个整体进行研究。本文旨在介绍Sigma-1受体研究及其知识结构的全球观点。方法：我们使用基本性质的文献计量学指标以及从Scopus数据库中提取的科学信息网络的可视化和分析技术。结果：从1992年到2017年，共识别出1，102篇文章。物品生产的增长在一段时间内并不稳定，大约有5年的停滞期。只有247名作者有5篇或更多的出版物。作者似乎分组在相对独立的集群中，从而表明致力于Sigma-1受体的人之间的合作水平较低。美国是产量最高的国家，其次是日本和德国。西班牙、日本和意大利的每百万居民比率最高。引用/文章比率最高的是法国、美国和加拿大。主要的研究机构是明斯特大学、国立卫生研究院、ESTEVE和CNOMM。发表文章数量最多的作者是Wunsch-B、Schepmann-D和MauriceT。Hayashi-T、Su-TP和Bowen-WD的篇均被引频次最高。Hayashi-T和Su-TP在Cell（2007）中描述Sigma-1受体作为伴侣蛋白的文章是引用最多的参考文献。来自作者共引分析的聚类标签表明，研究一直集中在特定的疾病，如成瘾，神经保护和神经退行性疾病，精神疾病和疼痛。作者关键词中的高频词表明，在某些领域的研究工作，如神经影像学，可卡因成瘾或精神疾病已经随着时间的推移而下降，而其他如神经退行性疾病或疼痛目前最受欢迎。提高研究绩效所需的额外推动力可能来自于将不同实验室的数据结合起来，以克服个别方法的局限性。由此产生的地图是一个有用的和有吸引力的工具，为Sigma-1受体研究社区，因为他们揭示了探索的主线一目了然。
Purpose: There are previous reviews focused on Sigma-1 receptor but no bibliometric studies examining this field as a whole. This article aims to present a global view of Sigma-1 receptor research and its intellectual structure.Methods: We used bibliometric indicators of a basic nature as well as techniques for the visualization and analysis of networks of scientific information extracted from Scopus database.Results: In total, 1,102 articles from 1992 to 2017 were identified. The growth in the production of articles is not constant over time, with periods of stagnation of approximately 5 years. Only 247 authors have five or more publications. The authors appear grouped in relatively independent clusters, thus suggesting a low level of collaborations between those dedicated to the Sigma-1 receptor. The United States was the country with the highest production followed by Japan and Germany. Spain, Japan, and Italy showed the highest per million inhabitants ratio. The highest citation/article ratio was reached in France, United States, and Canada. The leading institutions were the University of Munster, the National Institutes of Health, ESTEVE, and INSERM. The top authors in number of publications were Wunsch-B, Schepmann-D, and MauriceT. Hayashi-T, Su-TP and Bowen-WD showed the highest citations per article. The article by Hayashi-T and Su-TP in Cell (2007) describing the Sigma-1 receptor as a chaperone protein is the top cited reference. Cluster labeling from author co-citation analysis shows that research has been focused on specific diseases such as addiction, neuroprotection and neurodegenerative diseases, psychiatric disorders, and pain. High-frequency terms in author keywords suggest that the research efforts in some areas such as neuroimaging, cocaine addiction or psychiatric disorders have declined over time, while others such as neurodegenerative diseases or pain are currently most popular.Perspective: A greater involvement of the scientific community, with an increase in the scientific production related to Sigma-1, is desirable. Additional boost needed to improve research performance is likely to come from combining data from different laboratories to overcome the limitations of individual approaches. The resulting maps are a useful and attractive tool for the Sigma-1 receptor research community, as they reveal the main lines of exploration at a glance.