Amino Acid-Induced Thermogenesis to Prevent Hypothermia During Anesthesia Is Not Associated with Increased Stress Response
Amino Acid-Induced Thermogenesis to Prevent Hypothermia During Anesthesia Is Not Associated with Increased Stress Response
复制标题
氨基酸诱导产热以防止麻醉期间体温过低与应激反应增加无关
作者：
E. Selldén;S. Lindahl
术中输注氨基酸刺激氧的摄取，从而增加产热，特别是在出现从anesthesia.To确定是否增加产热反应的氨基酸输注期间和麻醉后诱导任何额外的压力在手术患者，血浆儿茶酚胺进行了测量。研究了14例年龄为44 +/- 15岁的异氟烷麻醉期间计划进行胆囊手术的患者。7名患者在整个麻醉过程中以126 mL/h的速率接受IV氨基酸输注，7名对照受试者接受等体积的无营养盐水。在麻醉期间和麻醉后的五个规定时间，测定动脉肾上腺素和去甲肾上腺素浓度。同时记录动脉血压和心率。在研究期间，血浆肾上腺素和去甲肾上腺素水平、心率和血压与基线相比有相当大的变化，但在整个麻醉和手术期间的任何时间，两组之间均无显著差异。总之，在麻醉期间和麻醉后出现时，氨基酸的产热作用增强，而不会对手术患者施加任何额外的压力。意义：麻醉期间输注氨基酸已被证明可显着增加耗氧量和产热。为了确定这是否会引起患者的任何压力，我们在麻醉期间测量了血浆儿茶酚胺。我们认为，温度保存在麻醉期间的氨基酸输液发生没有额外的交感肾上腺活动。（Anesth Analg 1998;87：637-40）
Intraoperative infusion of amino acids stimulates oxygen uptake with a resulting increase in heat production, especially during emergence from anesthesia.To determine whether the increased thermogenesis in response to amino acid infusion during and after anesthesia induces any additional stress in surgical patients, plasma catecholamines were measured. Fourteen patients aged 44 +/- 15 yr scheduled for gall bladder surgery during isoflurane anesthesia were studied. Seven patients received an IV amino acid infusion at the rate of 126 mL/h throughout anesthesia, and seven control subjects received equal volumes of nutrient-free saline. At five defined times during and after anesthesia, arterial adrenaline and noradrenaline concentrations were determined. Arterial blood pressure and heart rate were recorded simultaneously. There were considerable variations from baseline in levels of plasma adrenaline and noradrenaline, heart rate, and blood pressure during the study period, but there were no significant differences between the two groups at any time throughout anesthesia and surgery. In conclusion, the augmented thermogenic effect of amino acids during and at emergence from anesthesia is suggested to occur without imposing any additional stress in the surgical patient. Implications: Amino acid infusion during anesthesia has been demonstrated to markedly increase oxygen consumption and heat production. To determine whether this evokes any stress in the patients, we measured plasma catecholamines during anesthesia. We suggest that temperature preservation during anesthesia by an amino acid infusion occurs without additional sympathoadrenal activity. (Anesth Analg 1998;87:637-40)
影响因子：
158.5
作者：
Kurz, A;Sessler, DI;Lenhardt, R
通讯作者：
Lenhardt, R