Clinical and neuroimaging profile of congenital brain malformations in children with spastic cerebral palsy
Clinical and neuroimaging profile of congenital brain malformations in children with spastic cerebral palsy
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DOI：
10.2478/v10039-008-0006-z
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发表时间：
2008-06-01
影响因子：
2.7
通讯作者：
Okurowska-Zawada, B.
中科院分区：
文献类型：
--
作者：
Kulak, W.;Sobaniec, W.;Okurowska-Zawada, B.
目的：分析痉挛型脑瘫（CP）患儿先天性脑畸形的发生率。材料与方法：本研究纳入了74名男孩和56名女孩的痉挛性四肢瘫、双瘫和偏瘫CP，分析了CP患儿的MRI表现。结果：124例（95.3%）的MRI表现明显与CP相关。脑室周围白质软化症（PVL）在痉挛性双瘫儿童中比在四肢瘫痪或偏瘫患者中更常见。脑萎缩在全瘫患者中比在双瘫患者中更常见。脑孔囊肿多见于痉挛性偏瘫患儿。15例（10.7%）痉挛性脑瘫患儿有明显的先天性脑异常。脑畸形包括：裂脑畸形（5例）、胼胝体发育不全（4例）、多小回畸形（2例）、前脑无裂畸形（2例）和无裂脑畸形（2例）。顽固性癫痫和智力低下多见于脑异常患儿。先天性脑畸形12例足月出生，3例早产。结论：脑瘫患儿的神经影像学检查结果有助于确定脑瘫的病因和预后。
Purpose: Analysis of the incidence of congenital brain malformations in children with spastic cerebral palsy (CP) in a hospital-based study.Material and Methods: The present study included 74 boys and 56 girls with spastic tetraplegia, diplegia, and hemiplegia CP. Magnetic resonance imaging MRI findings were analyzed in children with CP.Results: Significant abnormalities relevant to the CP were evident on MRI in 124 (95.3%) subjects. Periventicular leukomalacia (PVL) was detected more frequently in children with spastic diplegia than in patients with tetraplegia or hemiplegia. Cerebral atrophy was found more often in the tetraplegic group compared to the diplegic patients. Porencephalic cysts were detected more often in children with spastic hemiplegia. Congenital brain anomalies were evident in 15 (10.7%) children with spastic CP. Brain malformations included: schizencephaly (5), agenesis corpus callosum (4), polymicrogyria (2), holoprosencephaly (2) and lissencephaly (2). Intractable epilepsy and mental retardation were observed more often in children with brain anomalies. Twelve patients with congenital brain malformations were born at term and three born at preterm.Conclusions: Neuroimaging results in children with CP may help determine the etiology and make better prognosis of CP.