Whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI
Whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI
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DOI：
10.1002/jmri.24809
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发表时间：
2015-08-01
影响因子：
4.4
通讯作者：
Ranjeva, Jean-Philippe
中科院分区：
文献类型：
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作者：
Lecocq, Angele;Le Fur, Yann;Ranjeva, Jean-Philippe
为了提高全脑定量三维(3D)磁共振波谱成像(MRSI)图的获得范围，并将其用于研究健康志愿者的脑代谢，方法在3特斯拉对10名健康志愿者进行两次短回波时间(20ms)的3D回波平面成像，一次在前连合-后连合面(AC-PC)平面，第二次在AC-PC+15°平面倾斜。进行了B-1(+)、B-1(-)和B-0校正程序，并用定量水质子密度测量对代谢物信号进行了归一化。两个空间归一化3D-MRSI的组合，使用基于从整个组获得的每个方向的像素标准差代谢图的加权平均值，提供每个受试者的代谢物图，从而获得自动解剖标记(AAL)图谱的所有地块的区域代谢物分布图。N-乙酰天冬氨酸(NAA)SD/平均值低于30%的AAL区域数量从AC-PC方向的17个和AC-PC+15度方向的41个增加到76个区域的值116。定量地描述了全脑绝对代谢物浓度(Mm)的地区差异，如额叶Gm(c(NAA)=10.03+1.71；c(CHO)=1.780.55；c(Cr)=7.29+/-1.69；c(Mins)=5.30+/-2.67)；小脑(c(NAA)=5.28+/-1.77；c(Cho)=1.60+/-0.41；c(Cr)=6.95+/-2.15；C(Mins)=3.60+/-0.74)。结论双角度采集可改善大范围脑体积的代谢特征。J·马根。雷森。成像2015；42：280-289。
BackgroundTo improve the extent over which whole brain quantitative three-dimensional (3D) magnetic resonance spectroscopic imaging (MRSI) maps can be obtained and be used to explore brain metabolism in a population of healthy volunteers.MethodsTwo short echo time (20 ms) acquisitions of 3D echo planar spectroscopic imaging at two orientations, one in the anterior commissure-posterior commissure (AC-PC) plane and the second tilted in the AC-PC +15 degrees plane were obtained at 3 Tesla in a group of 10 healthy volunteers. B-1(+), B-1(-), and B-0 correction procedures and normalization of metabolite signals with quantitative water proton density measurements were performed. A combination of the two spatially normalized 3D-MRSI, using a weighted mean based on the pixel wise standard deviation metabolic maps of each orientation obtained from the whole group, provided metabolite maps for each subject allowing regional metabolic profiles of all parcels of the automated anatomical labeling (AAL) atlas to be obtained.ResultsThe combined metabolite maps derived from the two acquisitions reduced the regional intersubject variance. The numbers of AAL regions showing N-acetyl aspartate (NAA) SD/Mean ratios lower than 30% increased from 17 in the AC-PC orientation and 41 in the AC-PC+15 degrees orientation, to a value of 76 regions of 116 for the combined NAA maps. Quantitatively, regional differences in absolute metabolite concentrations (mM) over the whole brain were depicted such as in the GM of frontal lobes (c(NAA)=10.03+1.71; c(Cho)=1.780.55; c(Cr)=7.29 +/- 1.69; c(mIns)=5.30 +/- 2.67) and in cerebellum (c(NAA)=5.28 +/- 1.77; c(Cho)=1.60 +/- 0.41; c(Cr)=6.95 +/- 2.15; c(mIns)=3.60 +/- 0.74).ConclusionA double-angulation acquisition enables improved metabolic characterization over a wide volume of the brain. J. Magn. Reson. Imaging 2015;42:280-289.