Activated protein C sensitivity ratio in pregnant women at delivery
Activated protein C sensitivity ratio in pregnant women at delivery
复制标题
孕妇分娩时活化蛋白C敏感性比
DOI：
10.1046/j.1365-2141.1996.00271.x
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发表时间：
1996
影响因子：
6.5
通讯作者：
Y. Giudicelli
中科院分区：
文献类型：
--
作者：
F. Mathonnet;Philippe Demazancourt;B. Bastenaire;M. Morot;N. Benattar;S. Beufé;J. Borg;Y. Giudicelli
我们研究了对照组妇女、口服避孕药妇女和分娩时孕妇的活化蛋白C敏感性比率（APC-SR）、因子V和VIII活性以及血管性血友病抗原。孕妇的平均APC-SR值为2.4，显着低于其他两组的平均APC-SR值3.5，并且45%的孕妇的比率低于对照组的第5百分位数。无一例携带R506→Q突变。这一下降的比例在交付似乎是连接，至少部分，与VIII活性增加。因此，分娩时的APC-SR不应用于检测APC耐药。
We studied activated protein C sensitivity ratio (APC‐SR), factors V and VIII activity and von Willebrand antigen in control women, women using oral contraceptives, and pregnant women at delivery. The mean APC‐SR of 2.4 in pregnant women was significantly lower than the mean APC‐SR value of 3.5 for both the other groups and 45% of pregnant women had a ratio below the 5th percentile of the control group. None of them carried the R506→Q mutation. This decreased ratio at delivery appeared to be connected, at least in part, with increased VIII activity. Thus, APC‐SR at delivery should not be used to detect APC resistance.