Spatial Differences in the Distribution of Bone Between Femoral Neck and Trochanteric Fractures.
Spatial Differences in the Distribution of Bone Between Femoral Neck and Trochanteric Fractures.
复制标题
DOI：
10.1002/jbmr.3150
复制
发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Cheng X
中科院分区：
文献类型：
--
作者：
Yu A;Carballido-Gamio J;Wang L;Lang TF;Su Y;Wu X;Wang M;Wei J;Yi C;Cheng X
股骨颈骨折和粗隆骨折股骨近端体积骨密度和皮质骨结构的空间分布差异知之甚少。在这项病例对照研究中，93例女性脆性髋部骨折、72例股骨颈骨折(平均年龄70.6±12.7岁)、21例股骨粗隆间骨折(75.6±9.3岁)和50例对照组(63.7±7.0岁)作为对照。采用基于体素的形态计量学(VBM)和基于表面的统计参数图(SPM)研究骨内膜邻近层的体积骨密度、皮质骨厚度、皮质体骨密度和体骨密度的空间分布差异。我们比较了对照组和两种骨折类型以及两种骨折类型之间的空间分布。使用VBM，我们发现对照组和髋部骨折患者之间的空间不均匀体积骨密度差异，这种差异因骨折类型而异。有趣的是，与对照组相比，股骨颈骨折受试者，而不是股骨粗隆骨折受试者，股骨颈上方的体积骨密度显著降低。使用基于表面的扫描电子显微镜，我们发现与对照组相比，两种骨折类型在与骨折类型一致的区域显示出更薄的皮质。皮质和皮质内体积骨密度比较的大多数结果与VBM结果一致。我们的结果提示：1)骨小梁体积骨密度的空间分布可能在髋部骨折中起重要作用；2)局灶性皮质骨变薄可能与股骨颈骨折更相关；3)皮质和皮质内体骨密度降低的区域可能与中国女性粗隆间骨折更相关。
There is little knowledge about the spatial distribution differences in volumetric bone mineral density and cortical bone structure at the proximal femur between femoral neck fractures and trochanteric fractures. In this case-control study, a total of 93 women with fragility hip fractures, 72 with femoral neck fractures (mean±SD age: 70.6±12.7 years) and 21 with trochanteric fractures (75.6±9.3 years), and 50 control subjects (63.7±7.0 years) were included for the comparisons. Differences in the spatial distributions of volumetric bone mineral density, cortical bone thickness, cortical volumetric bone mineral density and volumetric bone mineral density in a layer adjacent to the endosteal surface were investigated using voxel-based morphometry (VBM) and surface-based statistical parametric mapping (SPM). We compared these spatial distributions between controls and both types of fracture, and between the two types of fracture. Using VBM, we found spatially heterogeneous volumetric bone mineral density differences between control subjects and subjects with hip fracture, that varied by fracture type. Interestingly, femoral neck fracture subjects, but not subjects with trochanteric fracture, showed significantly lower volumetric bone mineral density in the superior aspect of the femoral neck compared to controls. Using surface-based SPM, we found that compared to controls both fracture types showed thinner cortices in regions in agreement with the type of fracture. Most outcomes of cortical and endocortical volumetric bone mineral density comparisons were consistent with VBM results. Our results suggest: 1) that the spatial distribution of trabecular volumetric bone mineral density might play a significant role in hip fracture; 2) that focal cortical bone thinning might be more relevant in femoral neck fractures; and 3) that areas of reduced cortical and endocortical volumetric bone mineral density might be more relevant for trochanteric fractures in Chinese women.
登录
查看更多内容
影响因子：
4.1
作者：
Li, Wenjun;Kornak, John;Lang, Thomas
通讯作者：
Lang, Thomas
影响因子：
4
作者：
Cooper, C.;Cole, Z. A.;Holroyd, C. R.;Earl, S. C.;Harvey, N. C.;Dennison, E. M.;Melton, L. J.;Cummings, S. R.;Kanis, J. A.
通讯作者：
Kanis, J. A.
影响因子：
2.3
作者：
Hey, Hwee Weng Dennis;Sng, Weizhong Jonathan;Kagda, Fareed H. Y.
通讯作者：
Kagda, Fareed H. Y.
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
3.5
作者：
Vaananen, Sami P.;Jurvelin, Jukka S.;Isaksson, Hanna
通讯作者：
Isaksson, Hanna