Calcium and phosphate plasma levels in dialysis patients after dietary Ca-P overload

DOI：

10.1159/000064290

发表时间：

2002-07-01

期刊：

NEPHRON

影响因子：

2.5

通讯作者：

中科院分区：

医学4区

文献类型：

作者：

Graziani, G;Badalamenti, S;Ponticelli, C

在正常受试者中，胃中钙和磷的电离似乎是其肠道吸收的先决条件。我们研究了30名接受常规透析治疗的患者在进食1g钙和2g磷酸盐后6小时内的血钙和血磷变化。此外，为了评估胃酸的作用，该研究在服用奥美拉唑3天后重复进行，以几乎消除胃酸分泌。基础研究中，血浆总钙和离子钙仅在餐后30min和120min达到峰值，而奥美拉唑给药后未见峰值。令人惊讶的是，无论是在基础试验还是在奥美拉唑研究中，血浆磷水平在试验餐后都没有增加。综上所述，与正常人一样，尿毒症透析患者饮食钙的胃电离促进了肠道钙的吸收，而奥美拉唑的急性胃酸抑制减少了肠道钙的转运。相反，在“权衡”假设下，我们没有观察到饮食负荷后任何餐后磷酸盐峰值，与正常受试者相比，给予奥美拉唑并没有影响磷酸盐分布。版权所有(C)2002 S.KargerAG，巴塞尔。

In normal subjects, the gastric ionisation of calcium and phosphate seems to be a prerequisite for their intestinal absorption. We investigated the behavior of the plasma calcium and phosphate profile in 30 patients on regular dialysis treatment in the 6 h following a meal containing 1 g of calcium and 2 g of phosphate. Moreover, to assess the role of gastric acidity, the study was repeated after 3 days on omeprazole administration, to nearly abolish gastric acid secretion. Both total plasma calcium and ionized calcium peaked after the meal (at 30 and 120 min, respectively) only in basal study, while no peak was observed after the administration of omeprazole. Surprisingly, both in basal and in the omeprazole study the levels of plasma phosphate did not increase after the test meal. In conclusion, as in normal subjects, the gastric ionization of dietary calcium promotes the intestinal absorption of calcium in uremic patients on dialysis treatment, while the acute gastric acid inhibition by omeprazole reduced the intestinal calcium transport. In contrast, with the 'trade off' hypothesis we did not observe any postprandial phosphate peak after the dietary load, and, in contrast with normal subjects, omeprazole administration did not influence the phosphate profile. Copyright (C) 2002 S. KargerAG, Basel.

Calcium and phosphate plasma levels in dialysis patients after dietary Ca-P overload - Role of gastric acid secretion

文献摘要

被引文献

相似文献