Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases
Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases
复制标题
内皮-间质转化：心血管疾病的新治疗靶点
DOI：
10.1016/j.tcm.2017.03.003
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发表时间：
2017-08-01
影响因子：
9.3
通讯作者：
Yin, Kai
中科院分区：
文献类型：
--
作者：
Jackson, Ampadu O.;Zhang, Jingjing;Yin, Kai
内皮细胞向间质细胞转化（EndMT）是一个复杂的生物学过程，其中内皮细胞失去其特异性标志物并获得间质或成肌纤维细胞表型。与上皮-间质转化（EMT）类似，EndMT可以由多种刺激物诱导，如细胞因子和代谢因子，其在心血管系统的发育中起关键作用。近年来的研究表明，EndMT在心血管疾病（CVD）的发病机制中起重要作用，并可能成为心血管重构和纤维化疾病的新的治疗靶点。然而，由于EndMT而发生的心血管发病机制中涉及的确切分子机制尚未完全解释。本文综述了EndMT的多种细胞间机制，包括兴奋剂、信号通路等，并试图探讨EndMT的生物学过程、心血管系统发育和心血管疾病之间的关系，以期为心血管疾病的治疗提供新的策略。
Endothelial-to-mesenchymal transition (EndMT) is a complex biological process in which endothelial cells lose their specific markers and acquire a mesenchymal or myofibroblastic phenotype. Similar to epithelial-to-mesenchymal transition (EMT), EndMT can be induced by multiple stimulants such as cytokines and metabolic factors that play crucial roles in the development of the cardiovascular system. Recent studies have demonstrated that EndMT may play a significant role in the pathogenesis of cardiovascular diseases (CVDs), and may represent a novel therapeutic target for cardiovascular remodeling and fibrotic disorders. The exact molecular mechanisms involved in cardiovascular pathogenesis that occur as a result of EndMT, however, are not fully explained. In this review, we reveal the multiple intercellular mechanisms of EndMT including stimulants, signaling pathways, and seek to explore the relationship between this biological process, cardiovascular system development, and CVDs that may lead to new therapeutic strategies for the treatment of CVDs.