HAIR-BUNDLE STIFFNESS DOMINATES THE ELASTIC REACTANCE TO OTOLITHIC-MEMBRANE SHEAR
HAIR-BUNDLE STIFFNESS DOMINATES THE ELASTIC REACTANCE TO OTOLITHIC-MEMBRANE SHEAR
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DOI：
10.1016/0378-5955(93)90128-n
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发表时间：
1993-08-01
期刊：
影响因子：
2.8
通讯作者：
HUDSPETH, AJ
中科院分区：
文献类型：
--
作者：
BENSER, ME;ISSA, NP;HUDSPETH, AJ
通过acousticolateralis器官的有效转导需要刺激力主要偏转发束，而不是弯曲其他结构元件。因此，毛束可能会提供一个大部分的阻力，耳石膜和其他附属结构的剪切运动。我们测量了牛蛙的囊状耳石膜的剪切运动的刚度，并确定了由于一个单一的毛束和其相关的细胞外丝的刚度，这个组件被称为元素刚度。通过位移其尖端与耳石膜耦合的柔性探针的底座，并同时测量探针的弯曲度和膜的位移来进行刚度测量。平均元件刚度约为1350 μ N。m-1，仅略微超过单个发束的刚度。因此，牛蛙球囊的毛束提供了刚度的主要组成部分，并因此占耳石膜剪切阻抗的重要组成部分。作为一个推论，发束的刚度变化或主动运动应该会影响这个和其他受体器官的机械反应。
Efficient transduction by acousticolateralis organs requires that a stimulus force principally deflect hair bundles, rather than flex other structural elements. Hair bundles might therefore be expected to provide a large fraction of the impedence to shear motions of otolithic membranes and other accessory structures. We measured the stiffness for shear motions of the bullfrog's saccular otolithic membrane, and determined the stiffness due to a single hair bundle and its associated extracellular filaments; this component is termed the elemental stiffness. Stiffness measurements were made by displacing the base of a flexible probe whose tip was coupled to the otolithic membrane, and simultaneously measuring the flexion of the probe and the displacement of the membrane. The average elemental stiffness, about 1350 muN . m-1, only modestly exceeded the stiffness of individual hair bundles. The hair bundles therefore provide the dominant component of stiffness in the bullfrog's sacculus, and thus account for a significant component of impedance to otolithic-membrane shear. As a corollary, stiffness changes or active movements in hair bundles should influence the mechanical responses of this and other receptor organs.