HLA antigens in the Landry‐Guillain‐Barré syndrome and chronic relapsing polyneuritis
HLA antigens in the Landry‐Guillain‐Barré syndrome and chronic relapsing polyneuritis
复制标题
兰德里-吉兰-巴利综合征和慢性复发性多发性神经炎中的 HLA 抗原
作者：
Fracp G. J. Stewart;Fracp J. D. Pollard;Fracp J. G. McLeod;BSc C. M. Wolnizer;D. Pollard
对 44 名炎性脱髓鞘性多发性神经炎患者（22 名兰德里-吉兰-巴利综合征患者、6 名亚急性多发性神经炎患者和 16 名慢性复发性多发性神经炎患者）进行了 6 号染色体 HLA 区域及其周围遗传标记的分型。慢性复发性多发性神经炎患者显示出与 HLA-AW30 和 AW31 明确相关，并可能与 HLA-B8、 HLA-DW3 和乙二醛酶 I。与 Landry-Guillain-Barré 综合征没有显着关联，尽管如果与慢性复发性多发性神经炎的分型结果相结合，乙二醛酶 I 的增加是显着的。整个患者组的 HLA-AW30、HLA-AW31 和 HLA-DW3 显着增加。结果支持这样的观点，即 HLA 相关遗传因素影响慢性复发性多发性神经炎的易感性，并可能导致周围神经系统炎症性脱髓鞘临床模式的差异。
Forty‐four patients with inflammatory demyelinating polyneuritis (22 with Landry‐Guillain‐Barré syndrome, 6 with subacute polyneuritis, and 16 with chronic relapsing polyneuritis) were typed for genetic markers in and around the HLA region of chromosome 6. Patients with chronic relapsing polyneuritis showed a definite association with HLA‐AW30 and AW31 and probable associations with HLA‐B8, HLA‐DW3, and glyoxalase I. No significant associations were demonstrated with the Landry‐Guillain‐Barré syndrome although an increase in glyoxalase I was significant if combined with the results of typing in chronic relapsing polyneuritis. The total patient group showed significant increases in HLA‐AW30, HLA‐AW31, and HLA‐DW3. The results support the view that HLA‐linked genetic factors influence susceptibility to chronic relapsing polyneuritis and may contribute to the differences in clinical patterns observed in inflammatory demyelination of the peripheral nervous system.