Caspases in T-cell receptor-induced thymocyte apoptosis.
Caspases in T-cell receptor-induced thymocyte apoptosis.
复制标题
T 细胞受体诱导的胸腺细胞凋亡中的 Caspases。
DOI：
10.1038/sj.cdd.4400513
复制
发表时间：
1999
影响因子：
12.4
通讯作者：
Lenardo,MJ
中科院分区：
文献类型：
--
作者：
Jiang,D;Zheng,L;Lenardo,MJ
Apoptosis eliminates inappropriate or autoreactive T lymphocytes during thymic development. Intracellular mediators involved in T-cell receptor (TCR)-mediated apoptosis in developing thymocytes during negative selection are therefore of great interest. Caspases, cysteine proteases that mediate mature T-cell apoptosis, have been implicated in thymocyte cell death, but their regulation is not understood. We examined caspase activities in distinct thymocyte subpopulations that represent different stages of T-cell development. We found caspase activity in CD4+ CD8+ double positive (DP) thymocytes, where selection involving apoptosis occurs. Earlier and later thymocyte stages exhibited no caspase activity. Only certain caspases, such as caspase-3 and caspase-8-like proteases, but not caspase-1, are active in DP thymocytes in vivo and can be activated when DP thymocytes are induced to undergo apoptosis in vitro by TCR-crosslinking. Thus, specific caspases appear to be developmentally regulated in thymocytes.
