ABSENCE OF MAJOR DEPRESSIVE DISORDER IN FEMALE CANCER-PATIENTS
ABSENCE OF MAJOR DEPRESSIVE DISORDER IN FEMALE CANCER-PATIENTS
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DOI：
10.1200/jco.1985.3.11.1553
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发表时间：
1985-01-01
影响因子：
45.3
通讯作者：
HENDRICKSON, FR
中科院分区：
文献类型：
--
作者：
LANSKY, SB;LIST, MA;HENDRICKSON, FR
这项调查评估了在五个预先指定的部位中的任何一个部位患有癌症的女性患者的抑郁症患病率。随机筛选了505名年龄在17至80岁的女性（190名乳腺癌，143名妇科恶性肿瘤，111名黑色素瘤，37名肠癌和24名淋巴瘤）。评估包括抑郁的汉密尔顿评定量表、Zung抑郁自评量表、Karnofsky表现量表和10 cm视觉疼痛模拟线。结果显示，平均汉密尔顿评分为10.2（范围：0 - 41;标准差：7.5），平均Zung评分为35.3（范围：11 - 68;标准差：9.6），Karnofsky评分中位数为80，疼痛评分中位数为0。Zung量表评分与汉密尔顿量表评分高度相关（r = 0.75）。基于被接受为指示抑郁症的截止分数（汉密尔顿. 20和Zung. 50例患者中，5.3%（27例）的患者有抑郁症状。与非抑郁女性相比，抑郁亚组的疼痛明显更多，经历了更大的身体残疾，并且更有可能有抑郁症的既往发作。当前抑郁症的两个最佳预测因素是表现状态（Karnofsky）和抑郁症史。没有发现抑郁症与其他人口统计学变量或疾病参数（诊断，自诊断以来的时间，疾病的阶段或阶段，以及当前的治疗）之间的关系。我们的研究结果表明，癌症患者中重度抑郁症的患病率低于许多以前的研究表明，福尔斯在一般人群中看到的范围内。
This investigation evaluated the prevalence of depression in female patients who had cancer in any of five predesignated sites. Five hundred five women aged 17 to 80 (190 with breast cancer, 143 with gynecologic malignancies, 111 with melanoma, 37 with bowel cancer, and 24 with lymphoma) were randomly screened. Assessment included the Hamilton rating scale for depression, the Zung self-rating depression scale, the Karnofsky performance scale, and a 10-cm visual pain analogue line. The results revealed a mean Hamilton of 10.2 (range, 0 to 41; SD, 7.5), a mean Zung score of 35.3 (range, 11 to 68; SD, 9.6), a Karnofsky median score of 80, and a median pain score of 0. Scores on the Zung scale were highly correlated with those of the Hamilton scale (r = .75). Based on cutoff scores accepted as indicating depression (Hamilton .gtoreq. 20 and Zung .gtoreq. 50), 5.3% (27) of the patients were depressed. The depressed subgroup was in significantly more pain, experienced greater physical disability, and was more likely to have had prior episodes of depression as compared to the nondepressed women. The two best predictors of current depression were performance status (Karnofsky) and history of depression. No relationship was found between depression and other demographic variables or disease parameters (diagnosis, time since diagnosis, stage or phase of illness, and current treatment). Our findings indicate that the prevalence of major depression in cancer patients is lower than many previous studies have indicated and falls within the range seen in the general population.