Fecundity of infertile women with minimal or mild endometriosis and women with unexplained infertility
Fecundity of infertile women with minimal or mild endometriosis and women with unexplained infertility
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DOI：
10.1016/s0015-0282(98)00081-8
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发表时间：
1998-06-01
影响因子：
6.7
通讯作者：
Maheux, R
中科院分区：
文献类型：
--
作者：
Bérubé, S;Marcoux, S;Maheux, R
目的：为了评估患有轻微或轻度子宫内膜异位症的不孕妇女是否比不明原因不孕妇女的生育力低，设计：前瞻性队列研究，地点：加拿大23家不孕症诊所，患者：331名年龄在20-39岁的不孕妇女，干预措施：诊断性腹腔镜检查不孕症。将患有轻微或轻度子宫内膜异位症的不孕妇女（n = 168）与不明原因不孕妇女（n = 263）进行比较。两组均按预期进行管理。这些妇女在腹腔镜检查后随访36周，或者对于那些怀孕的妇女，随访20周。主要结果测量：生育率是指在腹腔镜检查后的前36周内怀孕并怀孕大于或等于20周的概率。生育率是每100人月的怀孕次数。结果：生育率为18.2%的不孕妇女与轻微或轻度子宫内膜异位症和23.7%的妇女没有子宫内膜异位症（对数秩检验）。子宫内膜异位症妇女的生育率为2.52/100人月，不明原因不孕妇女的生育率为3.48/100人月。结果表明：子宫内膜异位症合并轻度或轻度子宫内膜异位症的不孕妇女的生育率与不明原因不孕妇女的生育率相比无显著性差异，其生育率的粗比值为0.72，校正比值为0.83（95%可信区间为0.53-1.32）。(C)1998年，美国生殖医学会。
Objective: To assess whether infertile women with minimal or mild endometriosis have lower fecundity than women with unexplained infertility.Design: Prospective cohort study.Setting: Twenty-three infertility clinics across Canada.Patient(s): Three hundred thirty-one infertile women aged 20-39 years.Intervention(s): Diagnostic laparoscopy for infertility. Infertile women with minimal or mild endometriosis (n = 168) were compared with women with unexplained infertility (n = 263). Both groups were managed expectantly. The women were followed up for 36 weeks after the laparoscopy or, for those who became pregnant, for up to 20 weeks of the pregnancy.Main Outcome Measure(s): Fecundity refers to the probability of becoming pregnant in the first 36 weeks after laparoscopy and carrying the pregnancy for greater than or equal to 20 weeks. The fecundity rate is the number of pregnancies per 100 person-months.Result(s): Fecundity was 18.2% in infertile women with minimal or mild endometriosis and 23.7% in women without endometriosis (log-rank test). The fecundity rate was 2.52 per 100 person-months in women with endometriosis and 3.48 per 100 person-months in women with unexplained infertility. The crude and adjusted fecundity rate ratios were 0.72 and 0.83 (95% confidence interval = 0.53-1.32), respectively.Conclusion(s): The fecundity of infertile women with minimal or mild endometriosis is not significantly lower than that of women with unexplained infertility. (C) 1998 by American Society for Reproductive Medicine.