ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
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DOI：
10.1016/s1097-2765(02)00740-2
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发表时间：
2002-11-01
期刊：
影响因子：
16
通讯作者：
Canaani, E
中科院分区：
文献类型：
--
作者：
Nakamura, T;Mori, T;Canaani, E
ALL-1是人类三胸/多梳基因家族的成员，也参与急性白血病。ALL-1存在于一个稳定的、非常大的多蛋白超复合物中，该复合物由大于或等于29种蛋白质组成。后者的大多数是人类转录复合物TFIID（包括TBP）、SWI/SNF、NuRD、hSNF 2 H和Sin 3A的组分。其他成分参与RNA加工或组蛋白甲基化。复合物重塑、乙酰化、脱乙酰化和甲基化核小体和/或游离组蛋白。该复合物的H3-K4甲基化活性由ALL-1 SET结构域赋予。染色质免疫沉淀表明，ALL-1和其他复杂的成分检查结合在一个活跃的ALL-1依赖性Hox α 9基因的启动子。平行地，H3-K4被甲基化，并且历史H3和H4在该启动子处被乙酰化。
ALL-1 is a member of the human trithorax/Polycomb gene family and is also involved in acute leukemia. ALL-1 is present within a stable, very large multiprotein supercomplex composed of greater than or equal to29 proteins. The majority of the latter are components of the human transcription complexes TFIID (including TBP), SWI/SNF, NuRD, hSNF2H, and Sin3A. Other components are involved in RNA processing or in histone methylation. The complex remodels, acetylates, deacetylates, and methylates nucleosomes and/or free histones. The complex's H3-K4 methylation activity is conferred by the ALL-1 SET domain. Chromatin immunoprecipitations show that ALL-1 and other complex components examined are bound at the promoter of an active ALL-1-dependent Hox a9 gene. In parallel, H3-K4 is methylated, and histories H3 and H4 are acetylated at this promoter.