Contrast-free ultrasound imaging for blood flow assessment of the lower limb in patients with peripheral arterial disease: a feasibility study.
Contrast-free ultrasound imaging for blood flow assessment of the lower limb in patients with peripheral arterial disease: a feasibility study.
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DOI：
10.1038/s41598-023-38576-x
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发表时间：
2023-07-13
影响因子：
4.6
通讯作者：
Alizad, Azra
中科院分区：
文献类型：
--
作者：
Sabeti, Soroosh;Nayak, Rohit;McBane, Robert D.;Fatemi, Mostafa;Alizad, Azra
下肢外周动脉疾病（peripheral arterial disease，PAD）是一种相对普遍的疾病，特别是在老年患者中，由于其症状不特异，常被误诊或漏诊。此外，在没有及时干预的情况下，PAD的进展可能导致可怕的后果。因此，开发非侵入性和负担得起的诊断方法可以非常有益于PAD患者的检测和治疗计划。在这项研究中，我们提出了一种基于无造影剂超声的定量血流成像技术用于PAD诊断。该方法包括监测小腿肌肉中的血流变化以响应大腿压力袖带引起的闭塞。四个定量指标引入这些变化的分析。这些指标包括阻塞后至基线血流强度变化（PBFIV）、总响应区域（TRR）、Lag0响应区域（L0RR）和Lag4（及更多）响应区域（L4 + RR）。我们通过一项由14名踝臂指数（ABI）异常的PAD患者和8名健康志愿者组成的体内研究来检查这种方法的可行性。分析从患者组中的13条腿和健康组中的13条腿采集的超声数据。在四个使用的度量中，三个在两组之间表现出显著不同的分布（p值< 0.05）。更具体地说，PBFIV的p值为0.0015，TRR为0.0183，L0RR为0.0048。该可行性研究的结果表明，所提出的方法用于检测PAD的诊断潜力。
While being a relatively prevalent condition particularly among aging patients, peripheral arterial disease (PAD) of lower extremities commonly goes undetected or misdiagnosed due to its symptoms being nonspecific. Additionally, progression of PAD in the absence of timely intervention can lead to dire consequences. Therefore, development of non-invasive and affordable diagnostic approaches can be highly beneficial in detection and treatment planning for PAD patients. In this study, we present a contrast-free ultrasound-based quantitative blood flow imaging technique for PAD diagnosis. The method involves monitoring the variations of blood flow in the calf muscle in response to thigh-pressure-cuff-induced occlusion. Four quantitative metrics are introduced for analysis of these variations. These metrics include post-occlusion to baseline flow intensity variation (PBFIV), total response region (TRR), Lag0 response region (L0RR), and Lag4 (and more) response region (L4 + RR). We examine the feasibility of this method through an in vivo study consisting of 14 PAD patients with abnormal ankle-brachial index (ABI) and 8 healthy volunteers. Ultrasound data acquired from 13 legs in the patient group and 13 legs in the healthy group are analyzed. Out of the four utilized metrics, three exhibited significantly different distributions between the two groups (p-value < 0.05). More specifically, p-values of 0.0015 for PBFIV, 0.0183 for TRR, and 0.0048 for L0RR were obtained. The results of this feasibility study indicate the diagnostic potential of the proposed method for the detection of PAD.
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