Mesenchymal stem cells and their microenvironment.
Mesenchymal stem cells and their microenvironment.
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DOI：
10.2741/3853
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发表时间：
2011-06
期刊：
影响因子：
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通讯作者：
I. Schraufstatter;R. Discipio;S. Khaldoyanidi
中科院分区：
文献类型：
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作者：
I. Schraufstatter;R. Discipio;S. Khaldoyanidi
间充质干细胞 (MSC) 是多能干细胞，有望扩大治疗用途，不仅因为它们能够分化为包括骨、脂肪和软骨在内的所有结缔组织，还因为它们的营养和抗炎作用有助于愈合和组织再生。正在进行的研究开始阐明支持间充质干细胞自我更新的微环境生态位的重要方面。在这篇综述中，我们总结了有关 MSC 自我更新与分化的调节，以及 MSC 在利基内的保留与动员和招募到损伤部位的细胞结构和分子途径的最新发现。此外，还讨论了间充质干细胞对造血和癌性微环境的结构和功能的贡献。
Mesenchymal stem cells (MSC) are multipotent stem cells that hold promise for an expanding list of therapeutic uses, not only due to their ability to differentiate into all connective tissues including bone, fat and cartilage, but additionally due to their trophic and anti-inflammatory effects which contribute to healing and tissue regeneration. Ongoing research is starting to illuminate important aspects of the microenvironmental niche, which supports MSC self-renewal. In this review, we summarize recent findings on cellular structures and molecular pathways that are involved in regulation of MSC self-renewal versus differentiation, and in retention of MSCs within the niche versus mobilization and recruitment to sites of injury. In addition, the contribution of MSCs to the structure and function of hematopoietic and cancerous niches is discussed.