Is it Really a Useful Index for Monitoring Training Follow-Up?
Is it Really a Useful Index for Monitoring Training Follow-Up?
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它真的是监控培训后续情况的有用指标吗？
DOI：
10.1055/s-2007-965187
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发表时间：
2007
影响因子：
2.5
通讯作者：
M. Fenske
中科院分区：
文献类型：
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作者：
M. Fenske
我饶有兴趣地阅读了Rouveix等人[b[14]]对年轻女子网球运动员训练和尿游离皮质醇（UFC）和皮质醇（UFCn）排泄进行监测的论文。他们认为，与最近的其他研究相似[b[1]，[6],[8]]， UFC/UFCn的比值是健康男性和女性肾脏11β-羟基类固醇脱氢酶2型活性的敏感指标，反映了矿化皮质激素的作用。他们的结论是：“我们的研究结果表明，夜间尿C/Cn比率的增加和E/NE比率的降低伴随着情绪状态和表现的改变，所有这些参数都与生理和心理压力有关。”24小时C/Cn的增加和E/NE比在训练期间的下降可能是疲劳和表现下降的预测标志。862)。我认为他们的研究存在缺陷，这使得他们的研究结果难以解释，甚至不可能解释。这些限制包括：(i) Rouveix等人[b[14]]在标题和文本中报道了24小时UFC/UFCn比率——另一方面，他们的结论涉及过夜尿（摘要的最后一段）；（二）他们说，“第二天早晨，发现利尿”（第394页）。859)。它们是什么意思？不应期望夜间或晨尿量异常大或稀释。他们研究的第三个也是最严重的局限性是，他们忽略了尿量变化可能产生的影响，尽管现在有充分的文献证明，人体内UFC[[4]，[5]，[13]]和UFCn[[2]，[3]，[4]]的排泄以及实验动物体内17-羟基皮质类固醇[[9]，[11]]的排泄取决于尿量。总之，关注尿量和尿游离糖皮质激素排泄之间的关系对于数据解释和减少尿游离糖皮质激素测量的不确定性至关重要。因此，UFC/UFCn比值可以作为监测11β-羟基类固醇脱氢酶2型功能变化的可靠指标，这可能为肾上腺对训练负荷变化的适应提供新的见解。
I read with great interest the paper of Rouveix et al.[[14]] who monitored training and excretion of urinary free cortisol (UFC) and cortisol (UFCn) in young female tennis players. They considered, similar with other recent studies [[1],[6],[8]], the ratio of UFC/UFCn as a sensitive index of renal 11β-hydroxysteroid dehydrogenase type 2 activity reflecting mineralocorticoid action in healthy males and females. They concluded that “our results reveal that an increase in overnight urinary C/Cn ratio and a decrease in E/NE ratio are concomitant with alterations in mood state and performance, all these parameters being associated with physical and psychological stress. An increase in 24 h C/Cn and a decrease in E/NE ratio along the training period may be predictive markers of tiredness and decreased performance”(p. 862). I believe there are shortcomings in their study that make the interpretation of their results difficult or even impossible. These limitations included (i) Rouveix et al.[[14]] reported on the 24-hour UFC/UFCn ratio in the title as well as in the text-on the other hand, their conclusion refers to overnight urines (the last paragraph of the summary);(ii) they stated that “the following morning, diuresis was noted”(p. 859). What did they mean? It should not be expected that the volume of overnight or morning urine is unusually large or diluted. The third and most serious limitation of their investigation is that they ignored the possible influence of variation in urine volume, although is it now well documented that the excretion of UFC [[4],[5],[13]] and UFCn [[2],[3],[4]] in human and of that of 17-hydroxycorticosteroids in laboratory animal species [[9],[11]] depends on urine volume.In conclusion, attention to the relationship between urine volume and urinary free corticosteroid excretion is crucial for data interpretation and for reducing the uncertainty associated with measures of urinary free corticosteroids. Then, the UFC/UFCn ratio may be used as a reliable index to monitor functional changes of the 11β-hydroxysteroid dehydrogenase type 2, which may provide new insights into the adaptation of the adrenal gland to variations in training loads.