ROLE OF CAPSAICIN- AND HEAT-SENSITIVE AFFERENTS IN STIMULATION OF ACUPOINT-INDUCED PAIN AND ANALGESIA IN HUMANS
ROLE OF CAPSAICIN- AND HEAT-SENSITIVE AFFERENTS IN STIMULATION OF ACUPOINT-INDUCED PAIN AND ANALGESIA IN HUMANS
复制标题
辣椒素和热敏传入在刺激人类穴位引起的疼痛和镇痛中的作用
DOI：
10.1016/j.neuroscience.2017.06.051
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发表时间：
2017-09-01
期刊：
影响因子：
3.3
通讯作者：
You, Hao-Jun
中科院分区：
文献类型：
--
作者：
Lei, Jing;Ye, Gang;You, Hao-Jun
采用视觉模拟疼痛量表（VAS）及其受试者分布、压痛阈（PPT）和热痛阈（HPT），研究了胃经足三里（ST 36）/上巨虚（ST 37）沿着穴位区内外辣椒素敏感性传入纤维在疼痛感知和调制中的作用。与非穴位区治疗相比，ST 36或ST 37穴位给予辣椒素（100 μ g/50 μ l）引起的疼痛强度最强，疼痛分布最广，其次是快速发作，双侧，持久的继发性机械痛觉过敏和较慢发作的继发性热痛觉减退（辣椒素治疗后1天）。不同穴位治疗之间，ST 36穴给予辣椒素的疼痛强度比ST 37穴给予辣椒素的疼痛强度更强，疼痛分布更广泛。43 ℃热针刺激ST_（36）穴30 ~ 45 min（15 min无明显影响）可显著增强HPT，对PPT无影响。肌肉注射引起的肌肉疼痛。注射5.8%生理盐水，用43 ℃电针刺激对侧ST 36穴，可减轻持续性肌肉疼痛，缩小疼痛面积，逆转HPT的下降。结果表明：（1）穴位和非穴位区域的痛觉反应存在显著差异，这可能与辣椒素敏感性传入神经的分布和作用不同有关。(2)无痛性热刺激是预防持续性肌肉疼痛以及外周和中枢致敏相关后效应的有效方法。(C)2017年IBRO。由爱思唯尔有限公司出版。保留所有权利。
We investigated role of capsaicin-sensitive afferents within and without the areas of Zusanli (ST36)/Shangjuxu (ST37) acupoints along the stomach (ST) meridian in the perception and modulation of pain assessed by visual analog scale of pain and its distribution rated by subjects, pressure pain threshold (PPT), and heat pain threshold (HPT) in humans. Compared with the treatment of non-acupoint area, capsaicin (100 mu g/50 mu l) administered into either ST36 or ST37 acupoint caused the strongest pain intensity and the most extensive pain distribution, followed by rapid onset, bilateral, long-lasting secondary mechanical hyperalgesia and slower onset secondary heat hypoalgesia (1 day after the capsaicin treatment). Between treatments of different acupoints, capsaicin administrated into the ST36 acupoint exhibited the stronger pain intensity and more widespread pain distribution compared with the treatment of ST37 acupoint. A period of 30- to 45-min, but not 15-min, 43 degrees C heating-needle stimulation applied to the ST36 acupoint significantly enhanced the HPT, and had no effect on PPT. Upon trapezius muscle pain elicited by the i.m. injection of 5.8% saline, pre-emptive treatment of the contralateral ST36 acupoint with 43 degrees C heating-needle stimulation alleviated the ongoing muscle pain, reduced painful area, and reversed the decrease in HPT. It is suggested that (1) pain elicited from the acupoint and non-acupoint areas differs significantly, which are supposed to be dependent on the different distributions and contributions of capsaicin-sensitive afferents. (2) Non-painful heat stimulation is a valid approach in prevention of ongoing muscle pain with associated post-effects of peripheral and central sensitization. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.