Neuromodulatory Regulation of Behavioral Individuality in Zebrafish.
Neuromodulatory Regulation of Behavioral Individuality in Zebrafish.
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DOI：
10.1016/j.neuron.2016.06.016
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发表时间：
2016-08-03
期刊：
影响因子：
16.2
通讯作者：
Isacoff EY
中科院分区：
文献类型：
--
作者：
Pantoja C;Hoagland A;Carroll EC;Karalis V;Conner A;Isacoff EY
个体间的行为变化被认为可以提高适应性，帮助适应环境变化，但潜在的机制尚不清楚。我们发现个体间神经调节输入的差异有助于斑马鱼（Danio Rerio）声惊吓反应（ASR）短期习惯化的个体化。ASR习惯在个体之间差异很大，但差异在数天内是稳定的，并且是可遗传的。激活asr命令毛特纳细胞的声刺激也激活了中隔背核（DRN）血清素能神经元，这些神经元投射到毛特纳细胞及其输入的附近。在适应过程中，DRN神经元的活动与适应成比例地减少，基因操作降低DRN神经元中的5 -羟色胺含量会增加习惯，而5 -羟色胺能激动作用或ChR2激活DRN会减少习惯。最后，DRN活动的退化程度与代际行为习惯的程度共同分离。因此，个体之间神经调节输入的差异有助于核心适应行为的个体性。脊椎动物行为个性的机制尚不清楚。Pantoja等人发现，个体在感觉诱发的神经调节输入方面的差异会调节行为，并与感觉诱发的适应行为中的行为差异共同隔离。因此，个体之间的神经调节差异有助于行为个性。
Inter-individual behavioral variation is thought to increase fitness and aid adaptation to environmental change, but the underlying mechanisms are poorly understood. We find that variation between individuals in neuromodulatory input contributes to individuality in short-term habituation of the zebrafish (Danio Rerio) acoustic startle response (ASR). ASR habituation varies greatly between individuals, but differences are stable over days and are heritable. Acoustic stimuli that activate ASR-command Mauthner cells also activate dorsal raphe nucleus (DRN) serotonergic neurons, which project to the vicinity of the Mauthner cells and their inputs. DRN neuron activity decreases during habituation in proportion to habituation and a genetic manipulation that reduces serotonin content in DRN neurons increases habituation, whereas serotonergic agonism or DRN activation with ChR2 reduces habituation. Finally, level of rundown of DRN activity co-segregates with extent of behavioral habituation across generations. Thus, variation between individuals in neuromodulatory input contributes to individuality in a core adaptive behavior. The mechanisms of vertebrate behavioral individuality are poorly understood. Pantoja et al. find that differences between individuals in sensory-evoked neuromodulatory input modulate behavior and co-segregate with behavioral differences in a sensory-evoked adaptive behavior. Thus, variation between individuals in neuromodulation contributes to behavioral individuality.