Increased colon cancer risk after severe Salmonella infection
Increased colon cancer risk after severe Salmonella infection
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DOI：
10.1371/journal.pone.0189721
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发表时间：
2018-01-17
期刊：
影响因子：
3.7
通讯作者：
Neefjes, Jacques
中科院分区：
文献类型：
--
作者：
Mughini-Gras, Lapo;Schaapveld, Michael;Neefjes, Jacques
背景结肠癌是最常见的恶性肿瘤之一。以前的研究表明，沙门氏菌操纵宿主细胞信号通路，鼠伤寒沙门氏菌感染促进遗传易感小鼠结肠癌的发展。本流行病学研究是否严重沙门氏菌感染，通常从受污染的食物中获得，与结肠癌的风险增加human.Methods和findingsWe进行了一项全国性的登记为基础的研究，以评估结肠癌的风险诊断沙门氏菌感染后。诊断出沙门氏菌病时年龄>= 20岁的荷兰居民（n = 14，264）的国家传染病监测记录（1999-2015年）与荷兰癌症登记处相关联。沙门氏菌感染的患者在患病1-2周后在医疗咨询下得到实验室确诊。这些数据集还包含沙门氏菌血清型和感染类型的信息。将诊断为沙门氏菌感染的患者的结肠癌风险（总体和每个结肠亚部位）与一般人群的预期结肠癌风险进行比较。来自全国组织和细胞病理学登记处（PALGA）和荷兰统计局（CBS）的数据允许评估年龄，性别，潜伏期，社会经济地位，遗传易感性，炎症性肠病（IBD）和肿瘤特征的潜在影响。我们发现，与普通人群相比，诊断为沙门氏菌感染的患者患结肠癌的风险显著增加（标准化发病率比[SIR] 1.54; 95%CI 1.09-2.10
BackgroundColon cancer constitutes one of the most frequent malignancies. Previous studies showed that Salmonella manipulates host cell signaling pathways and that Salmonella Typhimurium infection facilitates colon cancer development in genetically predisposed mice. This epidemiological study examined whether severe Salmonella infection, usually acquired from contaminated food, is associated with increased colon cancer risk in humans.Methods and findingsWe performed a nationwide registry-based study to assess colon cancer risk after diagnosed Salmonella infection. National infectious disease surveillance records (1999-2015) for Dutch residents aged >= 20 years when diagnosed with salmonellosis (n = 14,264) were linked to the Netherlands Cancer Registry. Salmonella-infected patients were laboratory-confirmed under medical consultation after 1-2 weeks of illness. These datasets also contained information on Salmonella serovar and type of infection. Colon cancer risk (overall and per colon subsite) among patients with a diagnosed Salmonella infection was compared with expected colon cancer risk in the general population. Data from the nationwide registry of histo-and cytopathology (PALGA) and Statistics Netherlands (CBS) allowed assessing potential effects of age, gender, latency, socioeconomic status, genetic predisposition, inflammatory bowel disease (IBD), and tumor features. We found that compared to the general population, colon cancer risk was significantly increased (standardized incidence ratio [SIR] 1.54; 95% CI 1.09-2.10) among patients with Salmonella infection diagnosed