Identification and characterization of nuclear pore subcomplexes in mitotic extract of human somatic cells
Identification and characterization of nuclear pore subcomplexes in mitotic extract of human somatic cells
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DOI：
10.1006/bbrc.1998.9953
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发表时间：
1999-01-19
影响因子：
3.1
通讯作者：
Yoneda, Y
中科院分区：
文献类型：
--
作者：
Matsuoka, Y;Takagi, M;Yoneda, Y
在高等真核细胞中，通常认为核孔复合体在有丝分裂开始时解体，在结束时重新组装。使用识别核孔抗原的单克隆抗体，我们发现，在哺乳动物体细胞Hela细胞的有丝分裂中，核孔复合物分解成至少三个亚复合物，称为亚复合物A、B和C（分子量：2 MDa
In higher eukaryotic cells, it is generally thought that nuclear pore complex disassembles at the beginning of mitosis and reassembles at the end. Using a monoclonal antibody that recognizes nuclear pore antigens, we found that, at mitosis of mammalian somatic Hela cells, the nuclear pore complex disassembles into at least three subcomplexes, termed subcomplexes A, B and C (molecular mass; 2 MDa