Nano-scale adhesion in multilayered drug eluting stents.
Nano-scale adhesion in multilayered drug eluting stents.
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DOI：
10.1016/j.jmbbm.2012.11.001
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发表时间：
2013-02
影响因子：
3.9
通讯作者：
S. Youssefian;N. Rahbar
中科院分区：
文献类型：
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作者：
S. Youssefian;N. Rahbar
不锈钢316L用于药物洗脱支架需要特殊的表面处理，因为金属表面与人体组织长时间接触会发生腐蚀现象。聚（邻氯-对二甲苯）（聚对二甲苯C）是以γ-甲基丙烯氧基三甲氧基硅烷为附着力促进剂，用于316L涂料的惰性和生物相容性材料之一。本研究采用原子力显微镜实验和接触理论相结合的方法，量化了硅烷添加的聚对二甲苯C/316L与硅烷添加的聚对二甲苯C/316L之间的粘附功。本文首先采用原子模拟的方法，对药物洗脱支架在室温下的粘附性能与实验结果进行了研究和比较，然后研究了体内温度较高的水环境对药物洗脱支架结构层间粘附性能的影响。316L简化模型的模拟结果与实验结果吻合较好，表明该聚合物与316L的紧密联系主要是由范德华相互作用引起的。温度对附着力的影响是退行性的，随着水分子渗透聚合物，附着力降低。结果还表明，硅烷对聚对二甲苯与钢的粘附性能影响不大。
Using stainless steel 316L for drug-eluting stents needs specific surface finishing due to corrosion phenomena that take place on the metal surface upon prolonged contact with human tissue. Poly (o-chloro-p-xylylene) (Parylene C) is one of the inert and biocompatible materials that are used for 316L coating with γ-methacryloxypropyltrimethoxysilane as an adhesion promoter. In this study, a combination of atomic force microscopy experiments and contact theories have been used to quantify the work of adhesion between parylene C/316L and silane added parylene C/316L. An atomistic simulation has been used, first, to investigate and compare the adhesion at the room temperature with the experiments and then, to investigate the effect of aqueous environment with higher temperature, inside the body, on the adhesion between layers in the structure of drug eluting stent. The simulation results of simplified model for 316L are in good agreement with the experimental results and suggest that the week affiliation between this polymer and 316L is mainly due to Van der Waals interactions. The effect of temperature on the adhesion is found to be regressive and as the water molecules permeate the polymer the adhesion decreases. They also imply that the effect of silane on the adhesion between parylene C and steel is modest.