Latest advances in the regulatory genes of adipocyte thermogenesis.
Latest advances in the regulatory genes of adipocyte thermogenesis.
复制标题
DOI：
10.3389/fendo.2023.1250487
复制
发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
能量不平衡导致肥胖：更多的能量摄入或更少的能量消耗，或两者兼而有之。肥胖可能是许多代谢紊乱的根源，如2型糖尿病和心血管疾病。解偶联蛋白1（uncoupling protein 1，UCP1）在产热脂肪细胞中高度表达，能将质子动力转化为热量，而不产生ATP，增加能量消耗。通过增加非颤抖性脂肪细胞产热来对抗肥胖及其相关代谢紊乱是一种有吸引力的策略。最近有报道脂肪细胞产热受几个新的基因调控。这些工作为激活脂肪细胞产热和抵抗肥胖提供了新的和潜在的靶点，如分泌蛋白ADISSP和EMC10，酶SSU72等。本文综述了脂肪细胞产热调控的最新研究，以期为这一课题提供更多的启示。
An energy imbalance cause obesity: more energy intake or less energy expenditure, or both. Obesity could be the origin of many metabolic disorders, such as type 2 diabetes and cardiovascular disease. UCP1 (uncoupling protein1), which is highly and exclusively expressed in the thermogenic adipocytes, including beige and brown adipocytes, can dissipate proton motive force into heat without producing ATP to increase energy expenditure. It is an attractive strategy to combat obesity and its related metabolic disorders by increasing non-shivering adipocyte thermogenesis. Adipocyte thermogenesis has recently been reported to be regulated by several new genes. This work provided novel and potential targets to activate adipocyte thermogenesis and resist obesity, such as secreted proteins ADISSP and EMC10, enzyme SSU72, etc. In this review, we have summarized the latest research on adipocyte thermogenesis regulation to shed more light on this topic.
影响因子：
3.9
作者：
Junes-Gill, Katiana S.;Gallaher, Timothy K.;Gluzman-Poltorak, Zoya;Miller, Joseph D.;Wheeler, Christopher J.;Fan, Xuemo;Basile, Lena A.
通讯作者：
Basile, Lena A.