A new caffeic acid tetramer from the Dracocephalum moldavica L.
A new caffeic acid tetramer from the Dracocephalum moldavica L.
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DOI：
10.1080/14786419.2017.1359168
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发表时间：
2018-02
影响因子：
2.2
通讯作者：
Jun-Liang Zhang;Ren-jie Yan;Ning Yu;Xue Zhang;Dai-Jie Chen;Tong Wu;Jianguo Xin
中科院分区：
文献类型：
--
作者：
Jun-Liang Zhang;Ren-jie Yan;Ning Yu;Xue Zhang;Dai-Jie Chen;Tong Wu;Jianguo Xin
摘要从龙头草（Dracocephalum moldavica L.）的地上部分中分离得到一种新的咖啡酸四聚体化合物（+）methyl rabdosiin(4)，以及7个已知的咖啡酸多聚体（1 - 3,5 - 8）和1个咖啡酸单体(9)，并通过1D和2D NMR和质谱分析确定了化合物的结构。采用MTT法观察化合物2 ~ 4对过氧化氢（H2O2）诱导的SD新生大鼠心肌细胞凋亡的保护作用。3种化合物在12.5 μg/mL浓度下表现出较强的保护活性。
Abstract A new caffeic acid tetramer compound, named (+) methyl rabdosiin (4), together with seven known caffeic acid multimers (1–3, 5–8) and one caffeic acid monomer (9), were isolated from the aerial parts of Dracocephalum moldavica L. The structures of these compounds were assigned on the basis of 1D and 2D NMR spectroscopic and mass spectrometry analyses. The protective effects of compounds 2–4 against hydrogen peroxide (H2O2)-induced apoptosis were evaluated in primary cardiomyocytes of SD neonatal rats in vitro by the MTT method. Three compounds exhibited potent protective activities at 12.5 μg/mL.