Metabolic regulation of mitochondrial dynamics.
Metabolic regulation of mitochondrial dynamics.
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DOI：
10.1083/jcb.201511036
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发表时间：
2016-02-15
期刊：
影响因子：
--
通讯作者：
Chan DC
中科院分区：
文献类型：
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作者：
Mishra P;Chan DC
线粒体以其在真核细胞中的中心生物能量作用而闻名，在真核细胞中，它们作为发电站从营养物的氧化中产生三磷酸腺苷。同时，这些细胞器是高度动态的，并经历融合，分裂，运输和降解。这些动态过程中的每一个对于维持健康的线粒体群体都是至关重要的。鉴于线粒体的核心代谢功能，线粒体动力学和生物能量学相互影响并不奇怪。我们回顾了线粒体的动态特性，重点是这些过程如何响应细胞信号事件以及它们如何影响代谢。
Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the same time, these organelles are highly dynamic and undergo fusion, fission, transport, and degradation. Each of these dynamic processes is critical for maintaining a healthy mitochondrial population. Given the central metabolic function of mitochondria, it is not surprising that mitochondrial dynamics and bioenergetics reciprocally influence each other. We review the dynamic properties of mitochondria, with an emphasis on how these processes respond to cellular signaling events and how they affect metabolism.