Neurobehavioural effects of developmental toxicity.
Neurobehavioural effects of developmental toxicity.
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DOI：
10.1016/s1474-4422(13)70278-3
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发表时间：
2014-03
期刊：
影响因子：
48
通讯作者：
Landrigan, Philip J.
中科院分区：
文献类型：
--
作者：
Grandjean, Philippe;Landrigan, Philip J.
神经发育障碍，包括自闭症、注意力缺陷多动障碍、阅读障碍和其他认知障碍，影响着全球数百万儿童，一些诊断似乎正在增加。工业化学品损害发育中的大脑是这种流行率上升的已知原因之一。2006年，我们进行了系统的综述，确定了五种工业化学品为发育性神经毒物：铅、甲基汞、多氯联苯、砷和甲苯。自2006年以来，流行病学研究记录了另外六种发育神经毒物--锰、氟化物、毒死蜱、二氯二苯基三氯乙烷、四氯乙烯和多溴联苯醚。我们推测，还有更多的神经毒物尚未被发现。为了控制发育性神经毒性的流行，我们提出了全球预防策略。不应推定未经测试的化学品对大脑发育是安全的，因此必须对现有使用的化学品和所有新化学品进行发育神经毒性测试。为了协调这些努力并加速将科学转化为预防，我们建议紧急成立一个新的国际信息交换中心。
Neurodevelopmental disabilities, including autism, attention-deficit hyperactivity disorder, dyslexia, and other cognitive impairments, affect millions of children worldwide, and some diagnoses seem to be increasing in frequency. Industrial chemicals that injure the developing brain are among the known causes for this rise in prevalence. In 2006, we did a systematic review and identified five industrial chemicals as developmental neurotoxicants: lead, methylmercury, polychlorinated biphenyls, arsenic, and toluene. Since 2006, epidemiological studies have documented six additional developmental neurotoxicants—manganese, fluoride, chlorpyrifos, dichlorodiphenyltrichloroethane, tetrachloroethylene, and the polybrominated diphenyl ethers. We postulate that even more neurotoxicants remain undiscovered. To control the pandemic of developmental neurotoxicity, we propose a global prevention strategy. Untested chemicals should not be presumed to be safe to brain development, and chemicals in existing use and all new chemicals must therefore be tested for developmental neurotoxicity. To coordinate these efforts and to accelerate translation of science into prevention, we propose the urgent formation of a new international clearinghouse.