Proteases in the evaluation of pancreatic function and pancreatic disease
Proteases in the evaluation of pancreatic function and pancreatic disease
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DOI：
10.1016/s0009-8981(99)00229-6
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发表时间：
2000-02-15
影响因子：
5
通讯作者：
Goldberg, DM
中科院分区：
文献类型：
--
作者：
Goldberg, DM
本文回顾了胰腺蛋白酶（重点是胰蛋白酶、胰凝乳蛋白酶和弹性蛋白酶）在慢性胰腺功能不全 (CPI) 的诊断和治疗中的作用，强调了过去 5 年的进展。还描述了这些酶在急性胰腺炎中的一些重要的新方面，包括它们在诊断中的作用以及它们在疾病发病机制中与胆囊收缩素的相互作用。还描述了最近对这些酶作为促进动物和人类受试者中癌症扩散的试剂的兴趣。采用分层方法来探索不同来源材料的测试的优点和局限性：血清、粪便、十二指肠抽吸物和非侵入性胰腺功能测试。粪便弹性蛋白酶-1 和粪便胰凝乳蛋白酶浓度分别在 CPI 诊断和治疗中的实际用途是从最近文献分析中吸取的主要教训之一，并构成了本综述的主要信息。 (C) 2000 Elsevier Science B.V. 保留所有权利。
This paper reviews the role of pancreatic proteases (focusing upon trypsin, chymotrypsin and elastase) in the diagnosis and management of chronic pancreatic insufficiency (CPI), emphasizing advances over the last 5 years. Some important novel aspects of these enzymes in acute pancreatitis are also described, including their role in diagnosis and their interaction with cholecystokinin in the pathogenesis of the disease. The recent interest in these enzymes as agents promoting the spread of cancer in animals and human subjects is also described. A hierarchical approach has been taken to explore the advantages and limitations of tests in different source materials: serum, feces, duodenal aspirate, and non-invasive pancreatic function tests. The practical usefulness of fecal elastase-l and of fecal chymotrypsin concentrations in diagnosis and management of CPI, respectively, is one of the major lessons to be learned from analysis of the recent literature, and forms the principal message of this review. (C) 2000 Elsevier Science B.V. All rights reserved.