The ventral tegmental area modulates intracortical microstimulation (ICMS)-evoked M1 activity in a time-dependent manner
The ventral tegmental area modulates intracortical microstimulation (ICMS)-evoked M1 activity in a time-dependent manner
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DOI：
10.1016/j.neulet.2016.01.047
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发表时间：
2016-03-11
影响因子：
2.5
通讯作者：
Takashima, Ichiro
中科院分区：
文献类型：
--
作者：
Kunori, Nobuo;Kajiwara, Riichi;Takashima, Ichiro
在大鼠初级运动皮层（M1）研究了皮层内微刺激（ICMS）联合腹侧被盖区（VTA）刺激诱发的神经活动。我们使用电压敏感染料（VSD）成像来分析VTA-M1配对刺激后M1活动的时空动态。VTA刺激之前，M1 ICMS在15-350 ms的刺激间隔（ISIS）。VSD成像显示了一个兴奋-抑制序列的神经活动后，组成VTA刺激和ICMS诱导的M1神经活动。为了评价净ICMS M1响应，从VTA-M1配对响应中减去对未配对VTA刺激的光学响应。这表明，净ICMS诱发的M1神经活动被抑制时，ISI为30-50毫秒，但高度促进时，ISI为100-350毫秒。这些结果表明，腹侧被盖区调制M1的兴奋性在几十到几百毫秒的顺序，并可能直接影响在M1的运动命令生成过程。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Intracortical microstimulation (ICMS)-evoked neural activity combined with ventral tegmental area (VTA) stimulation was studied in rat primary motor cortex (M1). We used voltage-sensitive dye (VSD) imaging to analyze the spatiotemporal dynamics of M1 activity following VTA-M1 paired stimulation. VTA stimulation was preceded by M1 ICMS at inter-stimulus intervals (ISIS) of 15-350 ms. VSD imaging showed an excitatory-inhibitory sequence of neural activity after composing VTA stimulus- and ICMS-induced M1 neural activity. To evaluate the net ICMS M1 response, the optical response to unpaired VTA stimulation was subtracted from the VTA-M1 paired response. This revealed that the net ICMS-evoked M1 neural activity was inhibited when the ISI was 30-50 ms, but highly facilitated when the ISI was 100-350 ms. These results suggest that VTA modulates M1 excitability in the order of tens to hundreds of milliseconds and might directly affect the motor command generation process in the M1. (C) 2016 Elsevier Ireland Ltd. All rights reserved.