Flexibility sustains epithelial tissue homeostasis.
Flexibility sustains epithelial tissue homeostasis.
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DOI：
10.1016/j.ceb.2019.04.009
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发表时间：
2019-10
影响因子：
7.5
通讯作者：
Karen Tai;Katie Cockburn;V. Greco
中科院分区：
文献类型：
--
作者：
Karen Tai;Katie Cockburn;V. Greco
上皮围绕着我们的身体，排列在我们的大部分器官中。内在的动态平衡机制在面对磨损、伤口，甚至是累积突变的情况下，补充和修复这些组织。细胞生物学、遗传学和活体成像技术的最新进展表明，在单个上皮细胞水平上，上皮细胞的动态平衡是一个本质上的灵活过程。这种动态平衡的灵活性对于我们如何看待更戏剧性的细胞可塑性具有重要的意义，这种可塑性通常被认为与病理环境有关。在这篇综述中，我们将重点介绍上皮细胞动态平衡的关键机制和过程，并阐述已知的上皮细胞相互作用的分子机制，以阐明上皮细胞是如何在生物体的整个生命周期中维持的。
Epithelia surround our bodies and line most of our organs. Intrinsic homeostatic mechanisms replenish and repair these tissues in the face of wear and tear, wounds, and even the presence of accumulating mutations. Recent advances in cell biology, genetics, and live-imaging techniques have revealed that epithelial homeostasis represents an intrinsically flexible process at the level of individual epithelial cells. This homeostatic flexibility has important implications for how we think about the more dramatic cell plasticity that is frequently thought to be associated with pathological settings. In this review, we will focus on key emerging mechanisms and processes of epithelial homeostasis and elaborate on the known molecular mechanisms of epithelial cell interactions to illuminate how epithelia are maintained throughout an organism’s lifetime.