Overview of the Matrisome-An Inventory of Extracellular Matrix Constituents and Functions
Overview of the Matrisome-An Inventory of Extracellular Matrix Constituents and Functions
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DOI：
10.1101/cshperspect.a004903
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发表时间：
2012-01-01
影响因子：
7.2
通讯作者：
Naba, Alexandra
中科院分区：
文献类型：
--
作者：
Hynes, Richard O.;Naba, Alexandra
许多生物体基因组序列的完成使得可以合理完整地定义细胞外基质（ECM）蛋白的补充。在哺乳动物中，这种“核心基质体”包含类似于300种蛋白质。此外，还存在大量ECM修饰酶、ECM结合生长因子和其他ECM相关蛋白。这些不同类别的ECM和ECM相关蛋白协同组装和重塑细胞外基质，并通过ECM受体与细胞结合。与ECM结合生长因子的受体一起，它们向细胞提供多种输入以控制细胞的存活、增殖、分化、形状、极性和运动性。ECM蛋白的进化是脊椎动物进化过程中向多细胞结构转变、细胞排列成组织层以及新结构形成的关键。ECM的这种关键作用反映在ECM蛋白的多样性和ECM蛋白的模块化结构域结构中，这两者都允许它们的多重相互作用，并且在进化过程中，发展出新的蛋白质结构。
Completion of genome sequences for many organisms allows a reasonably complete definition of the complement of extracellular matrix (ECM) proteins. In mammals this "core matrisome" comprises similar to 300 proteins. In addition there are large numbers of ECM-modifying enzymes, ECM-binding growth factors, and other ECM-associated proteins. These different categories of ECM and ECM-associated proteins cooperate to assemble and remodel extracellular matrices and bind to cells through ECM receptors. Together with receptors for ECM-bound growth factors, they provide multiple inputs into cells to control survival, proliferation, differentiation, shape, polarity, and motility of cells. The evolution of ECM proteins was key in the transition to multicellularity, the arrangement of cells into tissue layers, and the elaboration of novel structures during vertebrate evolution. This key role of ECM is reflected in the diversity of ECM proteins and the modular domain structures of ECM proteins both allow their multiple interactions and, during evolution, development of novel protein architectures.