The PIK3CA gene is mutated with high frequency in human breast cancers
The PIK3CA gene is mutated with high frequency in human breast cancers
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DOI：
10.4161/cbt.3.8.994
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发表时间：
2004-08-01
影响因子：
3.6
通讯作者：
Park, BH
中科院分区：
文献类型：
--
作者：
Bachman, KE;Argani, P;Park, BH
磷脂酰肌醇3 - 激酶（PI3Ks）是已知的细胞生长和增殖的调节因子。最近有报道称，PI3K亚基p110α（PIK3CA）内的体细胞突变存在于人类结直肠癌及其他癌症中。在此我们表明，53例乳腺癌中有13例（25%）在PIK3CA中存在体细胞突变，且大多数突变位于激酶结构域。这些结果证明PIK3CA是乳腺癌中突变最多的癌基因，并支持PIK3CA在上皮癌变中的作用。
The phosphatidylinositol 3-kinases (PI3Ks) are known regulators of cellular growth and proliferation. It has recently been reported that somatic mutations within the PI3K subunit p110alpha (PIK3CA) are present in human colorectal and other cancers. Here we show that thirteen of fifty-three breast cancers (25%) contain somatic mutations in PIK3CA, with the majority of mutations located in the kinase domain. These results demonstrate that PIK3CA is the most mutated oncogene in breast cancer and support a role for PIK3CA in epithelial carcinogenesis.