Expression of Fatty Acid-Binding Protein-3 in Gastrointestinal Stromal Tumors and Its Significance for Prognosis
Expression of Fatty Acid-Binding Protein-3 in Gastrointestinal Stromal Tumors and Its Significance for Prognosis
复制标题
脂肪酸结合蛋白3在胃肠道间质瘤中的表达及其对预后的意义。
DOI：
10.1016/j.jss.2020.11.003
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发表时间：
2021-03-06
影响因子：
2.2
通讯作者：
Xue, Wan-Jiang
中科院分区：
文献类型：
--
作者：
Chen, Xi;Hu, Shi-Liu;Xue, Wan-Jiang
背景：FABP3是脂肪酸结合蛋白（FABP）家族的一员，其在多种癌症中的作用已有报道。然而，关于FABP3在胃肠道间质瘤（gist）中的作用知之甚少。方法：应用免疫组织化学和组织芯片技术分析119例gist患者中FABP3的表达，探讨其表达与预后的关系。采用Kaplan-Meier分析，利用完整的随访资料计算患者生存率；采用Cox回归分析，评价FABP3的潜在预后价值。结果：免疫组化检测到fabp3阳性信号为位于细胞质中的棕色颗粒。在119个组织样本中，我们观察到64个FABP3高表达，55个低表达或阴性表达。免疫组化分析显示，FABP3表达与肿瘤大小（P = 0.006）、有丝分裂指数（P = 0.016）、大体分型（P = 0.048）、AFIP-Miettinen危险分型（P = 0.007）显著相关。多元logistic回归分析显示，FABP3的表达与肿瘤大小有显著相关性（P = 0.021）。Kaplan-Meier生存曲线显示，FABP3低表达、AFIP-Miettinen风险极低至中度的gist患者预后较好。多因素分析进一步表明，高表达的FABP3与较差的5年总生存率显著相关（P = 0.017）。结论：FABP3高表达对胃肠道间质瘤患者有预后价值。(c) 2020 Elsevier Inc.版权所有。
Background: FABP3 is a member of the fatty acid-binding protein (FABP) family, whose role in various cancers has been reported in the past. However, little is known about the role that FABP3 plays in gastrointestinal stromal tumors (GISTs).Methods: FABP3 expression was analyzed in 119 patients with GISTs using immunohistochemistry and tissue microarrays to interrogate the relationship between expression and prognosis. Kaplan-Meier analysis was used to calculate patient survival rates using complete follow-up data and to evaluate the potential prognostic value of FABP3 using Cox regression analysis.Results: FABP3-positive signals were detected as brown particles located in the cytoplasm using immunohistochemistry. Among the 119 tissue samples, we observed high FABP3 expression in 64 and low or negative expression in 55. Immunohistochemical analyses suggested that FABP3 expression was significantly correlated with tumor size (P = 0.006), mitotic index (P = 0.016), gross classification (P = 0.048), and AFIP-Miettinen risk classification (P = 0.007). Multiple logistic regression analysis showed that the expression of FABP3 was significantly associated with tumor size (P = 0.021). Kaplan-Meier survival curves showed that patients with GISTs with low expression of FABP3 and classified with a very low to moderate AFIP-Miettinen risk had better prognosis. Multivariate analysis further showed that high expression of FABP3 (P = 0.017) was significantly associated with poor 5 year overall survival.Conclusions: High FABP3 expression has a prognostic value for patients with GISTs.(c) 2020 Elsevier Inc. All rights reserved.