Early-Onset Inflammatory Bowel Disease
Early-Onset Inflammatory Bowel Disease
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DOI：
10.1016/j.iac.2018.08.008
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发表时间：
2019-02-01
影响因子：
2.6
通讯作者：
Sullivan, Kathleen E.
中科院分区：
文献类型：
--
作者：
Kelsen, Judith R.;Russo, Pierre;Sullivan, Kathleen E.
过去 4 年来，炎症性肠病的流行病学发生了变化。发病率急剧上升，发病年龄呈年轻化趋势。炎症性肠病的这种变化反映了一种新的认识，即患有炎症性肠病的最小儿童在患有潜在原发性免疫缺陷和单基因原因的病例中较多。这些病例的治疗可能有很大不同，特定的遗传病因支持独特的干预措施，有些需要造血细胞移植才能有效治疗。
The epidemiology of inflammatory bowel disease has changed over the past 4 decades. The incidence is rising dramatically and the age of onset has become younger. This changing landscape of inflammatory bowel disease reflects the new recognition that the youngest children with inflammatory bowel disease are enriched in cases with underlying primary immunodeficiency and monogenic causes. The management of these cases can be quite different, with specific genetic etiologies supporting unique interventions and some requiring hematopoietic cell transplantation for effective treatment.