DEVELOPMENT OF BLOOD VESSELS AND EXTRACELLULAR SPACES DURING POSTNATAL MATURATION OF RAT CEREBRAL CORTEX
DEVELOPMENT OF BLOOD VESSELS AND EXTRACELLULAR SPACES DURING POSTNATAL MATURATION OF RAT CEREBRAL CORTEX
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DOI：
10.1002/cne.901380104
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发表时间：
1970-01-01
影响因子：
2.5
通讯作者：
MAXWELL, DS
中科院分区：
文献类型：
--
作者：
CALEY, DW;MAXWELL, DS
作为一项关于出生后大鼠大脑皮层发育的更大研究的一部分，这份报告讨论了大脑皮层作为一个组织从出生到21天的成熟。光镜下观察细胞数密度、血管数密度和皮质厚度随年龄的变化，两者均与常规电子显微镜超微结构观察有关。皮质的成熟分为两个阶段：前10天，发育到成体大小，几乎没有通畅的血管，但有大的细胞外空间；后10天，大多数血管发展成通畅的管腔，星形胶质细胞末端足部的血管周围鞘发育，大的细胞外空间随着神经鞘的成熟而消失。血管在前10天似乎发展为中胚层元素的实心索，形成由原始血管组成的网络，原始血管具有厚壁和含有絮状物的狭缝状管腔。在第二个十天的早期，大多数血管在一段短的时间内明显同步形成充血的、开放的管腔。基板最初界限不清，但随着血管周围神经胶质鞘的发育而逐渐成熟。在轴突和树突快速生长阶段，当开放的血管较少时，细胞外间隙的体积最大。根据未成熟和成熟皮质中这些大的细胞外间隙可能的人工性质，讨论了这些大的细胞外间隙在血管和神经纤维成熟过程中的消失。
As part of a larger study of the development of postnatal rat cerebral cortex, this report deals with the maturation of the cortex as a tissue from birth to twenty‐one days of age. The changes in the numerical density of cells and blood vessels and the thickness of the cortex at successive ages were followed on light micrographs, and both were related to the ultrastructural observations on routine electron microscopic preparations. The maturation of the cortex is divided into two periods: The first ten days during which the growth to adult dimensions occurs and few patent blood vessels but large extracellular spaces are to be found, and the second ten days in which the majority of the vessels develop patent lumina, the perivascular sheath of astrocyte end‐feet develops, and the large extracellular spaces disappear concomitant with the maturation of the neuropil.The blood vessels appear to develop during the first ten days as solid cords of mesodermal elements which form a network of primordial vessels with thick walls and slit‐like lumina containing a flocculent material. The formation of a blood filled, patent lumen apparently occurs synchronously over a brief period of time for the majority of the vessels during the early part of the second ten‐day period. The basal lamina is ill‐defined initially but takes on mature appearance parallel with the development of the perivascular glial sheath.The volume of the extracellular space was found to be largest during the phase of rapid growth of axons and dendrites when few patent vessels exist. The disappearance of these large extracellular spaces during maturation of the blood vessels and neuropil is discussed in terms of the possible artifactitious nature of these spaces in both immature and mature cortex.