ATP binding cassette subfamily B member 9 (ABCB9) is a prognostic indicator of overall survival in ovarian cancer
ATP binding cassette subfamily B member 9 (ABCB9) is a prognostic indicator of overall survival in ovarian cancer
复制标题
DOI：
10.1097/md.0000000000015698
复制
发表时间：
2019-05-01
期刊：
影响因子：
1.6
通讯作者：
Liu, Ziling
中科院分区：
文献类型：
--
作者：
Hou, Lin;Zhang, Xueying;Liu, Ziling
卵巢癌（OC）是最常见的妇科恶性肿瘤之一，也是所有妇科恶性肿瘤中死亡率最高的。 ATP结合盒亚家族B成员9（ABCB9）是一种抗原加工样（TAPL）转运蛋白，越来越多的报道发现其参与多种恶性肿瘤的发生和进展。然而，ABCB9在OC中的潜在作用从未被报道过。本研究利用癌症基因组图谱（TCGA）数据库评估了正常卵巢组织和卵巢癌组织中ABCB9的表达。并通过卡方检验评估ABCB9表达与OC患者临床参数之间的关联。进行Kaplan-Meier分析和Cox回归分析来评估ABCB9的预后意义。 GSEA检测相关信号通路。OC中ABCB9表达量较正常卵巢组织显着降低（P
Ovarian cancer (OC) is one of the most common gynecological malignancies and owns the highest mortality rate among all gynecological malignant tumors. ATP binding cassette subfamily B member 9 (ABCB9) is an antigen processing-like (TAPL) transporter that has been found to be involved in the development and progression of various malignant tumors in accumulating reports. However, the potential role of ABCB9 in OC has never been reported.In this study, ABCB9 expression was evaluated in normal ovarian tissues and ovarian cancer tissues using The Cancer Genome Atlas (TCGA) database. And the associations between ABCB9 expression and clinical parameters of patients of OC were evaluated by Chi-square tests. Kaplan-Meier analysis and Cox regression analysis were performed to evaluate the prognostic significance of ABCB9. GSEA was performed to explore related signaling pathway.ABCB9 expression levels were significantly decreased in OC compared with normal ovarian tissues (P