Probing the mechanical unzipping of DNA
Probing the mechanical unzipping of DNA
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DOI：
10.1103/physrevlett.96.248101
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发表时间：
2006-06-23
影响因子：
8.6
通讯作者：
Rasmussen, K. O.
中科院分区：
文献类型：
--
作者：
Voulgarakis, N. K.;Redondo, A.;Rasmussen, K. O.
在Peyrard-Bishop-Dauxois模型的框架下研究了DNA的微机械解压缩。我们介绍了一种Monte Carlo技术，可以准确地确定的解压缩力的依赖解压缩速度和温度。我们的研究结果同意定量与实验结果均质的DNA，和噬菌体DNA，我们重现最近获得的实验力-温度相图。最后，我们认为，在体内和体外DNA解压缩之间可能有根本的区别。
A study of the micromechanical unzipping of DNA in the framework of the Peyrard-Bishop-Dauxois model is presented. We introduce a Monte Carlo technique that allows accurate determination of the dependence of the unzipping forces on unzipping speed and temperature. Our findings agree quantitatively with experimental results for homogeneous DNA, and for lambda-phage DNA we reproduce the recently obtained experimental force-temperature phase diagram. Finally, we argue that there may be fundamental differences between in vivo and in vitro DNA unzipping.