National Cancer Institute-supported chemotherapy-induced peripheral neuropathy trials: outcomes and lessons.
National Cancer Institute-supported chemotherapy-induced peripheral neuropathy trials: outcomes and lessons.
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DOI：
10.1007/s00520-015-3063-4
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发表时间：
2016-03
影响因子：
3.1
通讯作者：
Loprinzi, Charles L.
中科院分区：
文献类型：
--
作者：
Majithia, Neil;Temkin, Sarah M.;Ruddy, Kathryn J.;Beutler, Andreas S.;Hershman, Dawn L.;Loprinzi, Charles L.
化疗引起的周围神经病变（CIPN）是癌症治疗最常见且最令人衰弱的并发症之一。由于 CIPN 患者缺乏有效的治疗方案，美国国家癌症研究所 (NCI) 赞助了一系列旨在预防和治疗的试验。总共有 15 项此类研究获得批准，评估了各种神经调节剂的使用，这些药物已显示出对其他神经性疼痛状态的益处。除度洛西汀外，没有任何药理学方法显示出对 CIPN 患者的治疗益处。尽管结果令人失望，但这一系列试验揭示了重要的教训，为后续工作提供了参考。这方面的一些例子包括使用患者报告的症状指标、消除传统但未经证实的实践方法以及发现神经病的分子遗传预测因子。目前的调查是以这些大规模试验的结果为指导的，因此，更有可能找到针对这种限制治疗的毒性的持久解决方案。
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and debilitating complications of cancer treatment. Due to a lack of effective management options for patients with CIPN, the National Cancer Institute (NCI) sponsored a series of trials aimed at both prevention and treatment. A total of 15 such studies were approved, evaluating use of various neuro-modulatory agents which have shown benefit in other neuropathic pain states. Aside from duloxetine, none of the pharmacologic methods demonstrated therapeutic benefit for patients with CIPN. Despite these disappointing results, the series of trials revealed important lessons that have informed subsequent work. Some examples of this include the use of patient-reported symptom metrics, the elimination of traditional—yet unsubstantiated—practice approaches, and the discovery of molecular genetic predictors of neuropathy. Current inquiry is being guided by the results from these large-scale trials, and as such, stands better chance of identifying durable solutions for this treatment-limiting toxicity.
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影响因子：
3.8
作者：
Hershman, Dawn L.;Weimer, Louis H.;Crew, Katherine D.
通讯作者：
Crew, Katherine D.
影响因子：
11.2
作者：
Beutler, Andreas S.;Kulkarni, Amit A.;Kanwar, Rahul;Klein, Christopher J.;Therneau, Terry M.;Qin, Rui;Banck, Michaela S.;Boora, Ganesh K.;Ruddy, Kathryn J.;Wu, Yanhong;Smalley, Regenia L.;Cunningham, Julie M.;Le-Lindqwister, Nguyet Anh;Beyerlein, Peter;Schroth, Gary P.;Windebank, Anthony J.;Zuechner, Stephan;Loprinzi, Charles L.
通讯作者：
Loprinzi, Charles L.
影响因子：
3.1
作者：
Kottschade, Lisa A.;Sloan, Jeff A.;Mazurczak, Miroslaw A.;Johnson, David B.;Murphy, Bronagh P.;Rowland, Kendrith M.;Smith, DeAnne A.;Berg, Alan R.;Stella, Philip J.;Loprinzi, Charles L.
通讯作者：
Loprinzi, Charles L.
影响因子：
45.3
作者：
Hershman, Dawn L.;Unger, Joseph M.;Albain, Kathy S.
通讯作者：
Albain, Kathy S.
影响因子：
45.3
作者：
CASCINU, S;CORDELLA, L;CATALANO, G
通讯作者：
CATALANO, G