ADVERSE DRUG-REACTIONS - AN EPIDEMIOLOGICAL-STUDY AT PSYCHIATRIC-HOSPITALS
ADVERSE DRUG-REACTIONS - AN EPIDEMIOLOGICAL-STUDY AT PSYCHIATRIC-HOSPITALS
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DOI：
10.1111/j.1600-0447.1984.tb01185.x
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发表时间：
1984-01-01
影响因子：
6.7
通讯作者：
WOLF, B
中科院分区：
文献类型：
--
作者：
SCHMIDT, LG;GROHMANN, R;WOLF, B
自1979年以来，在柏林、哥廷根和慕尼黑（西德）的精神病大学医院建立了一个药物监测系统，以调查对精神药物的不良反应。本报告描述了该系统，并介绍了3年来获得的结果。随机选择504例患者，通过强化药物监测进行观察；75%的患者在住院期间发生药物不良反应（ADR），评估为可能、可能或明确，包括所有严重程度等级（I-III）。其他5096例患者在精神药物治疗期间通过有组织的自发报告进行监测；不良反应（ADR）是导致患者停药（严重程度为III级）的主要原因。10%。帕金森氏症、精神运动障碍、静坐障碍、谵妄、过度镇静和转氨酶升高是此类不良反应最常见的。计算ADR的相对频率，并建立最常停药的ADR谱。评估不良反应对患者持续治疗的影响。药物监测系统获得的可靠数据有望帮助有精神药物副作用特殊风险的患者做出治疗决定。
A drug monitoring system was established at psychiatric university hospitals in Berlin, Goettingen and Munich [West Germany] since 1979 in order to investigate adverse reactions to psychotropic drugs. This report describes the system and presents results obtained over 3 yr. Randomly selected patients (504) were observed by intensive drug monitoring; 75% of them had an adverse drug reaction (ADR) during hospitalization that was assessed as possible, probable or definite including all grades (I-III) of severity. Other patients (5096) were monitored by organized spontaneous reporting during treatment with psychotropic drugs; ADR were responsible for drug withdrawal (severity grade III) in .apprx. 10% of them. Parkinsonism, psychomotor disturbance, akathisia, delirium, oversedation and increased transaminases were the most frequent ADR of this kind. The relative frequency of ADR was calculated, and ADR-profiles established for drugs most frequently withdrawn. The impact of ADR on ongoing therapy of patients was assessed. Reliable data obtained by drug monitoring systems can be expected to aid in therapeutic decisions in patients with special risks of side effects to psychotropic drugs.