The BDNF Val66Met Polymorphism Is Associated With Rumination in Healthy Adults
The BDNF Val66Met Polymorphism Is Associated With Rumination in Healthy Adults
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DOI：
10.1037/a0016189
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发表时间：
2009-08-01
期刊：
影响因子：
4.2
通讯作者：
McGeary, John E.
中科院分区：
文献类型：
--
作者：
Beevers, Christopher G.;Wells, Tony T.;McGeary, John E.
本研究检查了反刍倾向与 2 个多态性之间的关联：脑源性神经营养因子 (BDNF) 基因中的 Val66Met 多态性和血清素转运蛋白基因 (SLC6A4) 中的 5-HTTLPR 多态性。参与者是一群健康、未接受药物治疗、从未抑郁过、目前很少有抑郁症状的个体 (N = 71)。结果表明，BDNF 等位基因的 met 杂合子比 val BDNF 等位基因纯合的个体更容易进行反刍。反刍与 5-HTTLPR 多态性之间没有关联。此外，5-HTTLPR 和 BDNF 多态性之间的相互作用并不能预测反刍。结果表明 BDNF 基因的变异可能导致反刍倾向。由于这种关联存在于健康成年人中，因此它可能代表情感障碍的易感因素。
This study examined associations between the tendency to ruminate and 2 polymorphisms: the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and 5-HTTLPR polymorphism in the serotonin transporter gene (SLC6A4). Participants were a homogeneous group of healthy, unmedicated, never depressed individuals with few current symptoms of depression (N = 71). Results indicated that met heterozygotes of the BDNF allele were significantly more likely to ruminate than individuals homozygous for the val BDNF allele. There was no association between rumination and the 5-HTTLPR polymorphism. Furthermore, the interaction between the 5-HTTLPR and BDNF polymorphisms did not predict rumination. Results suggest that variation in the BDNF gene may contribute to the tendency to ruminate. Because this association exists in healthy adults, it may represent a susceptibility factor for affective disorders.