Protein kinase C overactivity impairs prefrontal cortical regulation of working memory
Protein kinase C overactivity impairs prefrontal cortical regulation of working memory
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DOI：
10.1126/science.1100021
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发表时间：
2004-10-29
期刊：
影响因子：
56.9
通讯作者：
Arnsten, AFT
中科院分区：
文献类型：
--
作者：
Birnbaum, SG;Yuan, PX;Arnsten, AFT
前额叶皮层是大脑的一个高级区域，它通过表征性知识（通常被称为工作记忆）来调节思想、行为和情感。我们测试了蛋白激酶C （PKC）细胞内信号传导对前额叶皮层认知功能的影响，并表明前额叶皮层中PKC的高水平活动，如在压力暴露时所见，显著损害了工作记忆的行为和电生理测量。这些数据表明，过度的PKC激活会破坏前额皮质对行为和思维的调节，可能导致前额皮质功能障碍的迹象，如注意力不集中、判断力受损、冲动和思维障碍。
The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.