Boryl Radical-Promoted Deoxygenative Alkylation of Benzyl Acetates
Boryl Radical-Promoted Deoxygenative Alkylation of Benzyl Acetates
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DOI：
10.1055/s-0042-1751463
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发表时间：
2023-03
期刊：
影响因子：
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通讯作者：
Nan-Nan Liu-Nan;Xuan-Chen Wan;Li-Wen Hui;Feng-Lian Zhang;Yi‐Feng Wang
中科院分区：
文献类型：
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作者：
Nan-Nan Liu-Nan;Xuan-Chen Wan;Li-Wen Hui;Feng-Lian Zhang;Yi‐Feng Wang
以乙酸酯为醇活化基团，实现了苯甲醇的脱氧烷基化。 C-O键均裂是通过硼基自由基促进的β-断裂过程实现的。该策略适用于各种苯甲醇，包括伯醇、仲醇和更具挑战性的叔醇。通过克级一锅反应证明了合成的实用性。
Deoxygenative alkylation of benzyl alcohols was realized by using acetate as the alcohol activation group. The C–O bond homolysis is achieved by a boryl radical-promoted β-scission process. The strategy is amenable to a variety of benzyl alcohols, including primary, secondary, and more challenging tertiary alcohols. The synthetic practicability was demonstrated by a gram-scale one-pot reaction.