Telomere length predicts survival independent of genetic influences
Telomere length predicts survival independent of genetic influences
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DOI：
10.1111/j.1474-9726.2007.00340.x
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发表时间：
2007-12-01
期刊：
影响因子：
7.8
通讯作者：
Pedersen, Nancy L.
中科院分区：
文献类型：
--
作者：
Bakaysa, Stephanie L.;Mucci, Lorelei A.;Pedersen, Nancy L.
端粒可防止染色体复制过程中编码遗传物质的损失。先前的研究表明，端粒长度较短可能与较低的生存率有关。由于遗传因素对于端粒长度和死亡率的个体差异都很重要，因此该关联可能反映遗传或环境多效性，而不是端粒的直接生物学作用。我们通过对瑞典双胞胎的配对分析证明，高龄的端粒长度是一种生物标志物，可以预测早期家族环境和遗传因素与端粒长度和死亡率共同的影响之外的生存。端粒最短的双胞胎在随访期间的死亡风险高于其端粒测量最长的双胞胎[危险比（RR）= 2.8，95％置信区间1.1-7.3，p = 0.03] 。
Telomeres prevent the loss of coding genetic material during chromosomal replication. Previous research suggests that shorter telomere length may be associated with lower survival. Because genetic factors are important for individual differences in both telomere length and mortality, this association could reflect genetic or environmental pleiotropy rather than a direct biological effect of telomeres. We demonstrate through within-pair analyses of Swedish twins that telomere length at advanced age is a biomarker that predicts survival beyond the impact of early familial environment and genetic factors in common with telomere length and mortality. Twins with the shortest telomeres had a three times greater risk of death during the follow-up period than their co-twins with the longest telomere measurements [hazard ratio (RR) = 2.8, 95% confidence interval 1.1-7.3, P = 0.03].