Electrospun polycaprolactone matrices with tensile properties suitable for soft tissue engineering
Electrospun polycaprolactone matrices with tensile properties suitable for soft tissue engineering
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DOI：
10.3109/21691401.2014.998825
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发表时间：
2016-05-01
影响因子：
5.8
通讯作者：
Paul, Solomon F. D.
中科院分区：
文献类型：
--
作者：
Elamparithi, Anuradha;Punnoose, Alan M.;Paul, Solomon F. D.
细胞外环境是功能和结构组分的复杂网络，其赋予影响细胞功能和命运的化学和机械刺激。三维支架上的细胞分化也由基底的模量决定。电纺PCL纳米纤维，模仿细胞外基质，已经开发了各种各样的溶剂和它们的组合。各种研究表明，使用的溶剂影响物理和机械性能，导致杨氏模量在1.8-15.4 MPa范围内的支架，更适合于硬组织如骨的工程化。目前的研究描述了使用良性二元溶剂生成的纤维支架，其杨氏模量为36.05 +/- 13.08 kPa，这比来自常用溶剂的支架低近50倍，其特征在于成肌细胞，可以进一步探索其在肌肉和软组织工程中的应用。
The extracellular environment is a complex network of functional and structural components that impart chemical and mechanical stimuli that affect cellular function and fate. Cell differentiation on three dimensional scaffolds is also determined by the modulus of the substrate. Electrospun PCL nanofibers, which mimic the extra cellular matrix, have been developed with a wide variety of solvents and their combinations. The various studies have revealed that the solvents used influence the physical and mechanical properties, resulting in scaffolds with Young's modulus in the range of 1.8-15.4 MPa, more suitable for engineering of hard tissue like bone. The current study describes the use of benign binary solvent-generated fibrous scaffolds with a Young's modulus of 36.05 +/- 13.08 kPa, which is almost 50 times lower than that of scaffolds derived from the commonly used solvents, characterized with myoblast, which can be further explored for applications in muscle and soft tissue engineering.