Hepatoprotective Glucosyloxybenzyl 2-Hydroxy-2-isobutylsuccinates from Pleione yunnanensis.
Hepatoprotective Glucosyloxybenzyl 2-Hydroxy-2-isobutylsuccinates from Pleione yunnanensis.
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来自云南独叶兰 (Pleione yunnanensis) 的保肝葡糖氧基苄基 2-羟基-2-异丁基琥珀酸酯。
DOI：
10.1021/acs.jnatprod.0c01117
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发表时间：
2021
影响因子：
5.1
通讯作者：
Hamann,MarkT
中科院分区：
文献类型：
--
作者：
Han,Shao-Wei;Wang,Xiao-Juan;Cui,Bao-Song;Sun,Hua;Chen,Hui;Ferreira,Daneel;Li,Shuai;Hamann,MarkT
Nine new glucosyloxybenzyl 2-hydroxy-2-isobutylsuccinates, pleionosides M–U (1–9), and 12 known compounds (10–21) were isolated from the pseudobulbs ofPleione yunnanensis. Their structures and absolute configurations were established through a combination of HRESIMS and NMR data and supported by physical and chemical methods. Compounds5,6,10, and15showed significant in vitro hepatoprotective activity againstd-galactosamine (d-GalN)-induced toxicity in HL-7702 cells with increasing cell viability by 27%, 22%, 19%, and 31% compared to the model group (cf. bicyclol, 14%) at 10 μM, respectively. Compounds4,9, and11exhibited moderate hepatoprotective activity againstN-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with increasing cell viability by 9%, 16%, and 12% compared to the model group (cf. bicyclol, 9%) at 10 μM, respectively.
