Endocrinological characterization of an ovarian sex cord-stromal tumor with a Sertoli cell pattern in a Japanese Black cow
Endocrinological characterization of an ovarian sex cord-stromal tumor with a Sertoli cell pattern in a Japanese Black cow
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日本黑牛卵巢性索间质肿瘤的支持细胞模式的内分泌学特征
DOI：
10.1111/rda.13556
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发表时间：
2019
影响因子：
1.7
通讯作者：
Osawa T
中科院分区：
文献类型：
--
作者：
El-Sheikh Ali H;Kitahara G;Nibe K;Osawa T
评价了一头日本黑牛的产后乏情期延长和右侧卵巢增大。经直肠超音波检查显示右侧卵巢明显增大且呈实性外观，而左侧卵巢较小且无活性。与牛GTCT的诊断临界点相比，血浆抗苗勒管激素（AMH; 332.0 ng/ml）、雌二醇（E2; 103.3 pg/ml）和免疫反应性β-胡萝卜素（ir-INH; 2.1 ng/ml）显著升高，这支持了对颗粒卵泡膜细胞瘤（GTCT）的推定诊断。由于母牛不育且乳房肿胀，因此选择屠宰。组织学检查显示，肿瘤是卵巢性索间质肿瘤（SCST）与支持细胞模式。这些结果表明，血浆AMH、ir-INH和E2可能是具有Sertoli细胞模式的牛卵巢SCST的生物标志物，而该病例无法根据内分泌特征与GTCT区分。
A Japanese Black cow was evaluated for prolonged post‐partum anestrus and enlargement of the right ovary. Transrectal ultrasonography revealed that the right ovary was markedly enlarged and had a solid appearance, while the left ovary was small and inactive. The presumptive diagnosis was directed towards granulosa‐theca cell tumour (GTCT) which was supported by markedly elevated plasma anti‐Müllerian hormone (AMH; 332.0 ng/ml), oestradiol (E2; 103.3 pg/ml) and immunoreactive inhibin (ir‐INH; 2.1 ng/ml) in comparison with the diagnostic cut‐off points for bovine GTCTs. Since the cow had been infertile and had swelling of the udder, slaughter was chosen. Histopathological examination revealed that the tumour was an ovarian sex cord–stromal tumour (SCST) with a Sertoli cell pattern. These findings suggest that plasma AMH, ir‐INH and E2could be possible biomarkers for bovine ovarian SCST with a Sertoli cell pattern, whereas this case could not be distinguished from GTCTs based on endocrinological profile.